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The effect of maternal body mass index (BMI) and telomere function on in vitro fertilization (IVF) outcome: a preliminary cohort study.
Weeg, Natalie; Hershko Klement, Anat; Haikin, Einat; Amiel, Aliza; Shulman, Adrian; Biron-Shental, Tal; Wiser, Amir.
Afiliación
  • Weeg N; Obstetrics and Gynaecology Department, Meir Medical Centre, Kfar Saba, Israel.
  • Hershko Klement A; Obstetrics and Gynaecology Department, Meir Medical Centre, Kfar Saba, Israel.
  • Haikin E; Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.
  • Amiel A; The IVF Unit, Meir Medical Centre, Kfar Saba, Israel.
  • Shulman A; Obstetrics and Gynaecology Department, Meir Medical Centre, Kfar Saba, Israel.
  • Biron-Shental T; Department of Cytogenetics, Meir Medical Centre, Kfar Saba, Israel.
  • Wiser A; Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel.
Hum Fertil (Camb) ; 23(4): 282-288, 2020 Dec.
Article en En | MEDLINE | ID: mdl-30773064
Telomeres are a specific base sequence of DNA, responsible for chromosome stability and DNA protection. We aimed to investigate the association between telomere systems and IVF outcomes according to patients' BMI. For all telomere characteristics, there was a distinct trend towards shorter telomeres and activation of telomere shortening compensatory mechanisms in the BMI group >25 kg/m2, reaching statistical significance for senescence only (r = 0.7, p value <0.01). There was a trend towards a relationship between telomere length and number of oocytes between telomere length and fertilization rate, but these did not reach a statistical significance. For pregnancy outcome, all telomere characteristics were better for the patients who achieved a pregnancy. While there is paucity of data in the literature concerning the association between telomere characteristics and infertility, telomeres might contribute to the association between obesity and sub-optimal IVF results.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fertilización In Vitro / Índice de Masa Corporal / Homeostasis del Telómero Tipo de estudio: Etiology_studies / Incidence_studies / Observational_studies / Risk_factors_studies Límite: Adult / Female / Humans / Pregnancy Idioma: En Revista: Hum Fertil (Camb) Asunto de la revista: MEDICINA REPRODUTIVA Año: 2020 Tipo del documento: Article País de afiliación: Israel Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fertilización In Vitro / Índice de Masa Corporal / Homeostasis del Telómero Tipo de estudio: Etiology_studies / Incidence_studies / Observational_studies / Risk_factors_studies Límite: Adult / Female / Humans / Pregnancy Idioma: En Revista: Hum Fertil (Camb) Asunto de la revista: MEDICINA REPRODUTIVA Año: 2020 Tipo del documento: Article País de afiliación: Israel Pais de publicación: Reino Unido