Mass spectrometry based proteomic approach for the screening of butyrylcholinesterase adduct formation with organophosphates.

Dubrovskii, Yaroslav; Murashko, Ekaterina; Chuprina, Olga; Beltyukov, Petr; Radilov, Andrey; Solovyev, Nikolay; Babakov, Vladimir

Dubrovskii, Yaroslav; Murashko, Ekaterina; Chuprina, Olga; Beltyukov, Petr; Radilov, Andrey; Solovyev, Nikolay; Babakov, Vladimir.

Afiliación

Dubrovskii Y; St. Petersburg State University, Institute of Chemistry, St. Petersburg, Russian Federation; Research Institute of Hygiene, Occupational Pathology and Human Ecology, Federal Medical Biological Agency, St. Petersburg, Russian Federation. Electronic address: y.dubrovsky@spbu.ru.
Murashko E; Research Institute of Hygiene, Occupational Pathology and Human Ecology, Federal Medical Biological Agency, St. Petersburg, Russian Federation.
Chuprina O; Research Institute of Hygiene, Occupational Pathology and Human Ecology, Federal Medical Biological Agency, St. Petersburg, Russian Federation.
Beltyukov P; Research Institute of Hygiene, Occupational Pathology and Human Ecology, Federal Medical Biological Agency, St. Petersburg, Russian Federation.
Radilov A; Research Institute of Hygiene, Occupational Pathology and Human Ecology, Federal Medical Biological Agency, St. Petersburg, Russian Federation.
Solovyev N; St. Petersburg State University, Institute of Chemistry, St. Petersburg, Russian Federation.
Babakov V; Research Institute of Hygiene, Occupational Pathology and Human Ecology, Federal Medical Biological Agency, St. Petersburg, Russian Federation.

Talanta ; 197: 374-382, 2019 May 15.

Article en En | MEDLINE | ID: mdl-30771950

Asunto(s)

Butirilcolinesterasa/sangre; Organofosfatos/química; Proteoma/análisis; Animales; Butirilcolinesterasa/aislamiento & purificación; Butirilcolinesterasa/metabolismo; Cromatografía Liquida; Voluntarios Sanos; Caballos; Humanos; Organofosfatos/metabolismo; Espectrometría de Masas en Tándem

Palabras clave

Adducts; Cholinesterase; Covalent inhibition; Immunomagnetic separation; Organophosphorus compound; Target proteomics

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Organofosfatos / Butirilcolinesterasa / Proteoma Tipo de estudio: Diagnostic_studies / Screening_studies Límite: Animals / Humans Idioma: En Revista: Talanta Año: 2019 Tipo del documento: Article Pais de publicación: Países Bajos

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