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Bioactive homogentisic acid derivatives from fruits and flowers of Miliusa velutina.
Promgool, Trinop; Kanokmedhakul, Kwanjai; Tontapha, Sarawut; Amornkitbamrung, Vittaya; Tongpim, Saowanit; Jamjan, Winai; Kanokmedhakul, Somdej.
Afiliación
  • Promgool T; Natural Products Research Unit, Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Khon Kaen University, Khon Kaen 40002, Thailand.
  • Kanokmedhakul K; Natural Products Research Unit, Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Khon Kaen University, Khon Kaen 40002, Thailand.
  • Tontapha S; Integrated Nanotechnology Research Center, Department of Physics, Faculty of Science, Khon Kaen University, Khon Kaen 40002, Thailand.
  • Amornkitbamrung V; Integrated Nanotechnology Research Center, Department of Physics, Faculty of Science, Khon Kaen University, Khon Kaen 40002, Thailand.
  • Tongpim S; Department of Microbiology, Faculty of Science, Khon Kaen University, Khon Kaen 40002, Thailand.
  • Jamjan W; Department of Microbiology, Faculty of Science, Khon Kaen University, Khon Kaen 40002, Thailand.
  • Kanokmedhakul S; Natural Products Research Unit, Department of Chemistry and Center of Excellence for Innovation in Chemistry, Faculty of Science, Khon Kaen University, Khon Kaen 40002, Thailand. Electronic address: somdej@kku.ac.th.
Fitoterapia ; 134: 65-72, 2019 Apr.
Article en En | MEDLINE | ID: mdl-30768952
Chromatographic separation of fruits and flowers of the Thai medicinal plant, Miliusa velutina, resulted in the isolation of five new rare homogentisic acid derivatives, miliusanal (1) and miliusanones A-D (2-5), together with fifteen known secondary metabolites (6-20). Their structures were determined through the use of extensive spectroscopic data. The absolute configurations of homogentisic acid derivatives 2-7 were identified using NOESY data and a comparison of experimental and calculated ECD spectral data. Compounds 2, 3, 6, and 7 showed antimalarial activity with IC50 values in the range of 3.3-5.2 µg/mL. Compound 6 also showed activity against Mycobacterium tuberculosis with an MIC value of 50 µg/mL. Compounds 1-3, 6 and 7 exhibited cytotoxicity againt KB, MCF-7, NCI-H187 and Vero cell lines with IC50 values in the range of 5.8-40.4 µg/mL. In addition, compounds 1, 2 and 6 showed moderate antibacterial activities against three Gram-positive bacteria (Bacillus cereus, Staphylococcus aureus, and Methicillin resistant S. aureus) with MICs in the range of 32-64 µg/mL.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Annonaceae / Ácido Homogentísico / Antibacterianos / Antineoplásicos Fitogénicos Límite: Animals / Humans País/Región como asunto: Asia Idioma: En Revista: Fitoterapia Año: 2019 Tipo del documento: Article País de afiliación: Tailandia Pais de publicación: Países Bajos
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Annonaceae / Ácido Homogentísico / Antibacterianos / Antineoplásicos Fitogénicos Límite: Animals / Humans País/Región como asunto: Asia Idioma: En Revista: Fitoterapia Año: 2019 Tipo del documento: Article País de afiliación: Tailandia Pais de publicación: Países Bajos