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Successful cure of daptomycin-non-susceptible, vancomycin-intermediate Staphylococcus aureus prosthetic aortic valve endocarditis directed by synergistic in vitro time-kill study.
Sumon, Zarchi E; Berenson, Charles S; Sellick, John A; Bulman, Zackery P; Tsuji, Brian T; Mergenhagen, Kari A.
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  • Sumon ZE; a Department of Medicine, Infectious Diseases Division , University at Buffalo, Jacobs School of Medicine and Biomedical Sciences , Buffalo , NY , USA.
  • Berenson CS; a Department of Medicine, Infectious Diseases Division , University at Buffalo, Jacobs School of Medicine and Biomedical Sciences , Buffalo , NY , USA.
  • Sellick JA; b Department of Medicine, Infectious Diseases Division , Veterans Administration Western New York Healthcare System , Buffalo , NY , USA.
  • Bulman ZP; a Department of Medicine, Infectious Diseases Division , University at Buffalo, Jacobs School of Medicine and Biomedical Sciences , Buffalo , NY , USA.
  • Tsuji BT; b Department of Medicine, Infectious Diseases Division , Veterans Administration Western New York Healthcare System , Buffalo , NY , USA.
  • Mergenhagen KA; c Laboratory for Antimicrobial Pharmacodynamics , University at Buffalo School of Pharmacy and Pharmaceutical Sciences , Buffalo , NY , USA.
Infect Dis (Lond) ; 51(4): 287-292, 2019 04.
Article en En | MEDLINE | ID: mdl-30760062
Infectious complications following surgical valve replacements are extremely difficult to treat, often requiring prolonged antimicrobials therapy with or without surgery. Vancomycin-intermediate Staphylococcus aureus is an infrequent pathogen, with an estimated prevalence of less than 0.3%, but presents even greater challenges. We report a case of successful cure of daptomycin-non-susceptible and vancomycin-intermediate Staphylococcus aureus prosthetic valve endocarditis using an eight-week course of combination antimicrobial therapy. Using time-kill study, the combination of daptomycin plus ceftaroline and rifampin resulted in a greater than 4 log reduction of bacterial growth at 24 hours. This antimicrobial combination was used for a total of eight weeks with a successful outcome.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Prótesis Valvulares Cardíacas / Infecciones Relacionadas con Prótesis / Farmacorresistencia Bacteriana Múltiple / Endocarditis Bacteriana / Antibacterianos Tipo de estudio: Risk_factors_studies Límite: Aged / Humans / Male Idioma: En Revista: Infect Dis (Lond) Año: 2019 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Prótesis Valvulares Cardíacas / Infecciones Relacionadas con Prótesis / Farmacorresistencia Bacteriana Múltiple / Endocarditis Bacteriana / Antibacterianos Tipo de estudio: Risk_factors_studies Límite: Aged / Humans / Male Idioma: En Revista: Infect Dis (Lond) Año: 2019 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido