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Impact of adult attention deficit hyperactivity disorder and medication status on sleep/wake behavior and molecular circadian rhythms.
Coogan, A N; Schenk, M; Palm, D; Uzoni, A; Grube, J; Tsang, A H; Kolbe, I; McGowan, N M; Wandschneider, R; Colla, M; Oster, H; Thome, J; Faltraco, F.
Afiliación
  • Coogan AN; Department of Psychology, Maynooth University, National University of Ireland, Maynooth, Ireland.
  • Schenk M; Department of Psychiatry, Laboratory of Molecular Psychiatry, School of Medicine, University of Rostock, Rostock, Germany.
  • Palm D; Department of Psychiatry, Laboratory of Molecular Psychiatry, School of Medicine, University of Rostock, Rostock, Germany.
  • Uzoni A; Department of Psychiatry, Laboratory of Molecular Psychiatry, School of Medicine, University of Rostock, Rostock, Germany.
  • Grube J; Institute for Neurobiology, University of Lübeck, Lübeck, Germany.
  • Tsang AH; Institute for Neurobiology, University of Lübeck, Lübeck, Germany.
  • Kolbe I; Institute for Neurobiology, University of Lübeck, Lübeck, Germany.
  • McGowan NM; Department of Psychology, Maynooth University, National University of Ireland, Maynooth, Ireland.
  • Wandschneider R; Department of Psychiatry, University of Oxford, Oxford, UK.
  • Colla M; Department of Psychiatry, Laboratory of Molecular Psychiatry, School of Medicine, University of Rostock, Rostock, Germany.
  • Oster H; Department of Psychiatry, Laboratory of Molecular Psychiatry, School of Medicine, University of Rostock, Rostock, Germany.
  • Thome J; Institute for Neurobiology, University of Lübeck, Lübeck, Germany.
  • Faltraco F; Department of Psychiatry, Laboratory of Molecular Psychiatry, School of Medicine, University of Rostock, Rostock, Germany. johannes.thome@med.uni-rostock.de.de.
Neuropsychopharmacology ; 44(7): 1198-1206, 2019 06.
Article en En | MEDLINE | ID: mdl-30758328
Attention deficit hyperactivity disorder (ADHD) is a common neuropsychiatric condition that has been strongly associated with changes in sleep and circadian rhythms. Circadian rhythms are near 24-h cycles that are primarily generated by an endogenous circadian timekeeping system, encoded at the molecular level by a panel of clock genes. Stimulant and non-stimulant medication used in the management of ADHD has been shown to potentially impact on circadian processes and their behavioral outputs. In the current study, we have analyzed circadian rhythms in daily activity and sleep, and the circadian gene expression in a cohort of healthy controls (N = 22), ADHD participants not using ADHD-medication (N = 17), and participants with ADHD and current use of ADHD medication (N = 17). Rhythms of sleep/wake behavior were assessed via wrist-worn actigraphy, whilst rhythms of circadian gene expression were assessed ex-vivo in primary human-derived dermal fibroblast cultures. Behavioral data indicate that patients with ADHD using ADHD-medication have lower relative amplitudes of diurnal activity rhythms, lower sleep efficiency, more nocturnal activity but not more nocturnal wakenings than both controls and ADHD participants without medication. At the molecular level, there were alterations in the expression of PER2 and CRY1 between ADHD individuals with no medication compared to medicated ADHD patients or controls, whilst CLOCK expression was altered in patients with ADHD and current medication. Analysis of fibroblasts transfected with a BMAL1:luc reporter showed changes in the timing of the peak expression across the three groups. Taken together, these data support the contention that both ADHD and medication status impact on circadian processes.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trastorno por Déficit de Atención con Hiperactividad / Sueño / Ritmo Circadiano / Péptidos y Proteínas de Señalización del Ritmo Circadiano Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Neuropsychopharmacology Asunto de la revista: NEUROLOGIA / PSICOFARMACOLOGIA Año: 2019 Tipo del documento: Article País de afiliación: Irlanda Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trastorno por Déficit de Atención con Hiperactividad / Sueño / Ritmo Circadiano / Péptidos y Proteínas de Señalización del Ritmo Circadiano Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Neuropsychopharmacology Asunto de la revista: NEUROLOGIA / PSICOFARMACOLOGIA Año: 2019 Tipo del documento: Article País de afiliación: Irlanda Pais de publicación: Reino Unido