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Qualitative analysis and reproducibility assessment of the Scalp Itch Numeric Rating Scale among patients with moderate to severe plaque psoriasis of the scalp.
Wang, Yao; Coyne, Karin; Sofen, Howard; Santanello, Nancy; Currie, Brooke; Zhang, Zuoshun; Nograles, Kristine.
Afiliación
  • Wang Y; Celgene Corporation , Summit , NJ , USA.
  • Coyne K; Evidera , Bethesda , MD , USA.
  • Sofen H; David Geffen School of Medicine, UCLA , Los Angeles , CA , USA.
  • Santanello N; Consultant , Boston , MA , USA.
  • Currie B; Evidera , Bethesda , MD , USA.
  • Zhang Z; Celgene Corporation , Summit , NJ , USA.
  • Nograles K; Celgene Corporation , Summit , NJ , USA.
J Dermatolog Treat ; 30(8): 775-783, 2019 Dec.
Article en En | MEDLINE | ID: mdl-30747550
Background: Pruritus is a prevalent and bothersome symptom of scalp psoriasis. Validated scales assessing scalp itch are needed to evaluate treatment efficacy. Objective: To evaluate comprehensibility and reproducibility of the Scalp Itch Numeric Rating Scale (NRS), a novel scale being used in a phase 3 study of apremilast. Methods: The Scalp Itch NRS, Modified Whole Body Itch NRS, Global Assessment of Psoriasis Severity-Scalp (GAPS-S), and Global Impression of Change-Scalp Itch (GIC-SI) were assessed among patients with moderate to severe scalp psoriasis. Convergent validity and test-retest reliability between two visits (7 ± 3 days apart) were assessed using intra-class and Spearman's correlations. Results: Patients found the Scalp Itch NRS easy to use and understand. Convergent validity (Modified Whole Body Itch NRS Visit 1: rs = 0.71, Visit 2: rs = 0.92, p< .0001; GAPS-S Visit 1: rs = 0.62, Visit 2: rs = 0.63, p< .0001), and consistency with changes (Modified Whole Body Itch NRS: rs = 0.69, p< .0001; GAPS-S: rs = 0.42, p = .0029) were demonstrated. The Scalp Itch NRS showed strong test-retest reliability (intra-class correlation coefficient = 0.87; rs = 0.89). Change scores on the Scalp Itch NRS were consistent with change scores on the GIC-SI. Conclusions: The Scalp Itch NRS is a valid and reproducible measure of scalp itch in patients with moderate to severe scalp psoriasis. ClinicalTrials.gov: NCT03123471.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Prurito / Psoriasis / Cuero Cabelludo Tipo de estudio: Etiology_studies / Observational_studies / Prevalence_studies / Qualitative_research / Risk_factors_studies Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: J Dermatolog Treat Asunto de la revista: DERMATOLOGIA Año: 2019 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Prurito / Psoriasis / Cuero Cabelludo Tipo de estudio: Etiology_studies / Observational_studies / Prevalence_studies / Qualitative_research / Risk_factors_studies Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: J Dermatolog Treat Asunto de la revista: DERMATOLOGIA Año: 2019 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido