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High intensity exercise for 3 months reduces disease activity in axial spondyloarthritis (axSpA): a multicentre randomised trial of 100 patients.
Sveaas, Silje Halvorsen; Bilberg, Annelie; Berg, Inger Jorid; Provan, Sella Arrestad; Rollefstad, Silvia; Semb, Anne Grete; Hagen, Kåre Birger; Johansen, Melissa Woll; Pedersen, Elisabeth; Dagfinrud, Hanne.
Afiliación
  • Sveaas SH; National Advisory Unit for Rehabilitation in Rheumatology, Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway.
  • Bilberg A; Institute of Neuroscience and Physiology, Section of Health and Rehabilitation, Physiotherapy, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
  • Berg IJ; Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway.
  • Provan SA; Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway.
  • Rollefstad S; Preventive Cardio-Rheuma clinic, Department of Rheumatology, Diakonhjemme Hospital, Oslo, Norway.
  • Semb AG; Preventive Cardio-Rheuma clinic, Department of Rheumatology, Diakonhjemme Hospital, Oslo, Norway.
  • Hagen KB; National Advisory Unit for Rehabilitation in Rheumatology, Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway.
  • Johansen MW; Department of Physiotherapy, Martina Hansens Hospital, Bærum, Norway.
  • Pedersen E; Department of Physiotherapy, University Hospital of North Norway, Tromsø, Norway.
  • Dagfinrud H; National Advisory Unit for Rehabilitation in Rheumatology, Department of Rheumatology, Diakonhjemmet Hospital, Oslo, Norway.
Br J Sports Med ; 54(5): 292-297, 2020 Mar.
Article en En | MEDLINE | ID: mdl-30745314
BACKGROUND: Exercise is considered important in the management of patients with rheumatic diseases, but the effect of high intensity exercises on disease activity is unknown. OBJECTIVE: To investigate the effectiveness of high intensity exercises on disease activity in patients with axial spondyloarthritis (axSpA). METHOD: Assessor blinded multicentre randomised controlled trial. 100 patients (aged from their 20s to their 60s) with axSpA were randomly assigned to an exercise group or to a no-intervention control group. The exercise group performed cardiorespiratory and muscular strength exercises at high intensity over 3 months. The control group received standard care and was instructed to maintain their usual physical activity level. Primary outcome was disease activity measured with the Ankylosing Spondylitis (AS) Disease Activity Scale (ASDAS, higher score=worst) and the Bath AS Disease Activity Index (BASDAI, 0-10, 10=worst). Secondary outcomes were inflammatory markers, physical function and cardiovascular (CV)-health. There was patient involvement in the design and reporting of this study. RESULTS: 97 of the 100 (97%) randomised patients completed the measurements after the intervention. There was a significant treatment effect of the intervention on the primary outcome (ASDAS: -0.6 [-0.8 to -0.3], p<0.001 and BASDAI: -1.2 [-1.8 to -0.7], p<0.001). Significant treatment effects were also seen for inflammation, physical function and CV-health. CONCLUSION: High intensity exercises reduced disease symptoms (pain, fatigue, stiffness) and also inflammation in patients with axSpA. It improves patients' function and CV health. This debunks concerns that high intensity exercise might exacerbate disease activity in patients with axSpA. TRIAL REGISTRATION NUMBER: NCT02356874.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Espondiloartritis / Terapia por Ejercicio / Entrenamiento de Fuerza / Entrenamiento de Intervalos de Alta Intensidad Tipo de estudio: Clinical_trials Límite: Adult / Humans / Middle aged Idioma: En Revista: Br J Sports Med Año: 2020 Tipo del documento: Article País de afiliación: Noruega Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Espondiloartritis / Terapia por Ejercicio / Entrenamiento de Fuerza / Entrenamiento de Intervalos de Alta Intensidad Tipo de estudio: Clinical_trials Límite: Adult / Humans / Middle aged Idioma: En Revista: Br J Sports Med Año: 2020 Tipo del documento: Article País de afiliación: Noruega Pais de publicación: Reino Unido