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Effects of stanniocalcin hormones on rat brown adipose tissue metabolism under fed and fasted conditions.
Sarapio, Elaine; Souza, Samir Khal; Vogt, Everton Lopes; Rocha, Débora Santos; Fabres, Rafael Bandeira; Trapp, Marcia; Da Silva, Roselis S M.
Afiliación
  • Sarapio E; Department of Physiology, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil. Electronic address: elainesarapio@gmail.com.
  • Souza SK; Department of Physiology, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil.
  • Vogt EL; Department of Physiology, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil.
  • Rocha DS; Department of Physiology, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil.
  • Fabres RB; Department of Physiology, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil.
  • Trapp M; Department of Physiology, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil.
  • Da Silva RSM; Department of Physiology, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil. Electronic address: roselis@ufrgs.br.
Mol Cell Endocrinol ; 485: 81-87, 2019 04 05.
Article en En | MEDLINE | ID: mdl-30738951
In this study we determined the effect of fed and fasting (48 h) states on the expression of stanniocalcin-1 (Stc1) and stanniocalcin-2 (Stc2) in rat brown adipose tissue (BAT), as well as the in vitro effects of human stanniocalcin 1 and 2 (hSTC-1 and hSTC-2) hormones on lipid and glucose metabolism. In addition, lactate, glycogen levels and hexokinase (HK) activity were determined. In fasting Stc2 expression increased markedly. The targets of action of hSTC-1 and hSTC-2 were glucose uptake and oxidation as well as glycogen storage, controlling the energetic metabolism in BAT. The reduction in glycogen concentration induced by hSTC-2 in fed state might have deleterious consequences in BAT, such as decreased thermogenic activity, FA esterification and other adipocyte functions. On the other hand, the increase of glucose uptake caused by hSTC-1 of fed rats could play a role as a plasma glucose-clearing hormone in the postprandial period.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Tejido Adiposo Pardo / Glicoproteínas / Péptidos y Proteínas de Señalización Intercelular / Glucosa Límite: Animals / Humans / Male Idioma: En Revista: Mol Cell Endocrinol Año: 2019 Tipo del documento: Article Pais de publicación: Irlanda
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Tejido Adiposo Pardo / Glicoproteínas / Péptidos y Proteínas de Señalización Intercelular / Glucosa Límite: Animals / Humans / Male Idioma: En Revista: Mol Cell Endocrinol Año: 2019 Tipo del documento: Article Pais de publicación: Irlanda