Drugging RB1 Deficiency: Synthetic Lethality with Aurora Kinases.

Dick, Frederick A; Li, Shawn Shun-Cheng

Dick, Frederick A; Li, Shawn Shun-Cheng.

Afiliación

Dick FA; Department of Biochemistry, Western University, London, Ontario, Canada. fdick@uwo.ca.
Li SS; Department of Oncology, Western University, London, Ontario, Canada.

Cancer Discov ; 9(2): 169-172, 2019 02.

Article en En | MEDLINE | ID: mdl-30737214

RESUMEN

Two recent reports describe pharmacologic approaches to specifically treat RB1-mutant cancers. The basis of this approach is a synthetic lethal relationship between RB1 mutations and inhibition of Aurora kinases A or B.See related article by Oser et al., p. 230.See related article by Gong et al., p. 248.

Asunto(s)

Aurora Quinasa A; Neoplasias/genética; Genes Supresores de Tumor; Humanos; Mutación; Mutaciones Letales Sintéticas

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Aurora Quinasa A / Neoplasias Límite: Humans Idioma: En Revista: Cancer Discov Año: 2019 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Estados Unidos

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