<i>O</i>-GlcNAcylation alters the selection of mRNAs for translation and promotes 4E-BP1-dependent mitochondrial dysfunction in the retina.

Dierschke, Sadie K; Miller, William P; Favate, John S; Shah, Premal; Imamura Kawasawa, Yuka; Salzberg, Anna C; Kimball, Scot R; Jefferson, Leonard S; Dennis, Michael D

O-GlcNAcylation alters the selection of mRNAs for translation and promotes 4E-BP1-dependent mitochondrial dysfunction in the retina.

Dierschke, Sadie K; Miller, William P; Favate, John S; Shah, Premal; Imamura Kawasawa, Yuka; Salzberg, Anna C; Kimball, Scot R; Jefferson, Leonard S; Dennis, Michael D.

Afiliación

Dierschke SK; From the Department of Cellular and Molecular Physiology, Penn State College of Medicine, Hershey, Pennsylvania 17033.
Miller WP; From the Department of Cellular and Molecular Physiology, Penn State College of Medicine, Hershey, Pennsylvania 17033.
Favate JS; the Department of Genetics, Rutgers University, Piscataway, New Jersey 08854.
Shah P; the Department of Genetics, Rutgers University, Piscataway, New Jersey 08854.
Imamura Kawasawa Y; the Department of Pharmacology, Penn State College of Medicine, Hershey, Pennsylvania 17033, and.
Salzberg AC; the Department of Biochemistry and Molecular Biology, Institute for Personalized Medicine, Penn State College of Medicine, Hershey, Pennsylvania 17033.
Kimball SR; From the Department of Cellular and Molecular Physiology, Penn State College of Medicine, Hershey, Pennsylvania 17033.
Jefferson LS; From the Department of Cellular and Molecular Physiology, Penn State College of Medicine, Hershey, Pennsylvania 17033.
Dennis MD; From the Department of Cellular and Molecular Physiology, Penn State College of Medicine, Hershey, Pennsylvania 17033, mdennis@psu.edu.

J Biol Chem ; 294(14): 5508-5520, 2019 04 05.

Article en En | MEDLINE | ID: mdl-30733333

Asunto(s)

Proteínas Portadoras/metabolismo; Retinopatía Diabética/metabolismo; Proteínas del Ojo/metabolismo; Mitocondrias/metabolismo; Fosfoproteínas/metabolismo; Biosíntesis de Proteínas; ARN Mensajero/metabolismo; Retina/metabolismo; Acilación; Proteínas Adaptadoras Transductoras de Señales; Animales; Proteínas Portadoras/genética; Proteínas de Ciclo Celular; Retinopatía Diabética/genética; Retinopatía Diabética/patología; Factores Eucarióticos de Iniciación; Proteínas del Ojo/genética; Femenino; Ratones; Ratones Noqueados; Mitocondrias/genética; Mitocondrias/patología; Consumo de Oxígeno/efectos de los fármacos; Fosfoproteínas/genética; Piranos/farmacología; ARN Mensajero/genética; Especies Reactivas de Oxígeno/metabolismo; Retina/patología; Tiazoles/farmacología

Palabras clave

O-linked N-acetylglucosamine (O-GlcNAc); RiboSeq; diabetes; eukaryotic translation initiation; eukaryotic translation initiation factor 4E-binding protein 1 (EIF4EBP1); oxidative stress; post-translational modification (PTM); retina; ribosome foot printing

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Fosfoproteínas / Retina / Biosíntesis de Proteínas / ARN Mensajero / Proteínas Portadoras / Retinopatía Diabética / Proteínas del Ojo / Mitocondrias Límite: Animals Idioma: En Revista: J Biol Chem Año: 2019 Tipo del documento: Article Pais de publicación: Estados Unidos

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