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An integrated neurocognitive and social-cognitive treatment for youth at clinical high risk for psychosis: Cognition for Learning and for Understanding Everyday Social Situations (CLUES).
Friedman-Yakoobian, M; Parrish, E M; Thomas, A; Lesser, R; Gnong-Granato, A; Eack, S; Keshavan, M S.
Afiliación
  • Friedman-Yakoobian M; Public Psychiatry Division of Department of Psychiatry, Harvard Medical School at Beth Israel Deaconess Medical Center, 75 Fenwood Road, Boston, MA 02115, United States of America. Electronic address: mfriedm3@bidmc.harvard.edu.
  • Parrish EM; Public Psychiatry Division of Department of Psychiatry, Harvard Medical School at Beth Israel Deaconess Medical Center, 75 Fenwood Road, Boston, MA 02115, United States of America.
  • Thomas A; University of Alabama Health System, United States of America.
  • Lesser R; Cedars Sinai Medical Center, United States of America.
  • Gnong-Granato A; The Plymouth Center for Behavioral Health, United States of America.
  • Eack S; University of Pittsburgh School of Social Work and Department of Psychiatry, United States of America.
  • Keshavan MS; Public Psychiatry Division of Department of Psychiatry, Harvard Medical School at Beth Israel Deaconess Medical Center, 75 Fenwood Road, Boston, MA 02115, United States of America.
Schizophr Res ; 208: 55-59, 2019 06.
Article en En | MEDLINE | ID: mdl-30733169
BACKGROUND: Cognitive deficits, a core feature contributing to disability in schizophrenia, are present in milder form in individuals at clinical high risk (CHR) for psychosis. This study investigated the feasibility of Cognition for Learning and Understanding Everyday Social Situations (CLUES), an integrated neurocognitive and social cognitive treatment for youth at CHR. METHOD: This was an open, pilot feasibility trial. Seventeen individuals meeting CHR criteria were assessed prior to and following participation in CLUES for changes in symptoms, social and role functioning, and cognition. Participant attitudes towards CLUES were also examined. RESULTS: Participants significantly improved in social functioning [t(16) = -4.20, p = .001, d = 1.02], and trended for improvement in reaction time [t(15) = 2.09, p = .054, d = 0.52] from baseline to end of treatment. No other measures significantly changed. No participants transitioned to full psychosis during the treatment and follow up period. Participants reported they generally liked CLUES and found it helpful. CONCLUSION: While limited by the small sample size and the open label design, our preliminary results indicate that CLUES is feasible and shows promise in improving social functioning. However, further investigation is warranted in order to determine its efficacy. Future directions should include conducting a randomized controlled trial in order to compare the efficacy of CLUES to another intervention.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trastornos Psicóticos / Percepción Social / Disfunción Cognitiva / Habilidades Sociales / Remediación Cognitiva Tipo de estudio: Clinical_trials / Etiology_studies / Risk_factors_studies Límite: Adolescent / Adult / Female / Humans / Male Idioma: En Revista: Schizophr Res Asunto de la revista: PSIQUIATRIA Año: 2019 Tipo del documento: Article Pais de publicación: Países Bajos
Texto completo
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XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trastornos Psicóticos / Percepción Social / Disfunción Cognitiva / Habilidades Sociales / Remediación Cognitiva Tipo de estudio: Clinical_trials / Etiology_studies / Risk_factors_studies Límite: Adolescent / Adult / Female / Humans / Male Idioma: En Revista: Schizophr Res Asunto de la revista: PSIQUIATRIA Año: 2019 Tipo del documento: Article Pais de publicación: Países Bajos