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Altered Corneal Nerves in Chinese Thyroid-Associated Ophthalmopathy Patients Observed by In Vivo Confocal Microscopy.
Wu, Lian-Qun; Mou, Pei; Chen, Zi-Yu; Cheng, Jin-Wei; Le, Qi-Hua; Cai, Ji-Ping; Wei, Rui-Li.
Afiliación
  • Wu LQ; Department of Ophthalmology, Eye and Ear, Nose, and Throat (ENT) Hospital of Fudan University, Shanghai, China (mainland).
  • Mou P; Department of Ophthalmology, Changzheng Hospital, Second Military Medical University, Shanghai, China (mainland).
  • Chen ZY; Department of Ophthalmology, Changzheng Hospital, Second Military Medical University, Shanghai, China (mainland).
  • Cheng JW; Department of Ophthalmology, Changzheng Hospital, Second Military Medical University, Shanghai, China (mainland).
  • Le QH; Department of Ophthalmology, Changzheng Hospital, Second Military Medical University, Shanghai, China (mainland).
  • Cai JP; Department of Ophthalmology, Eye and Ear, Nose, and Throat (ENT) Hospital of Fudan University, Shanghai, China (mainland).
  • Wei RL; Department of Ophthalmology, Changzheng Hospital, Second Military Medical University, Shanghai, China (mainland).
Med Sci Monit ; 25: 1024-1031, 2019 Feb 06.
Article en En | MEDLINE | ID: mdl-30724266
BACKGROUND Thyroid-associated ophthalmopathy (TAO) is a common endocrine autoimmune disease. The present study explored corneal nerve changes in TAO patients. MATERIAL AND METHODS Thirty-eight Chinese TAO patients and 20 healthy individuals were included in the study. Central corneal subbasal nerve density and morphology were evaluated with in vivo laser scanning confocal microscopy and quantified using automated CCmetrics software. RESULTS The values of the central corneal subbasal nerve plexus parameters of both active and inactive TAO patients were significantly decreased compared with those of controls, including corneal nerve fiber density (CNFD) (P<0.001 for both), corneal nerve branch density (CNBD) (P<0.001 for both), corneal nerve fiber length (CNFL) (P<0.001 for both), corneal nerve fiber total branch density (CTBD) (P<0.001 for both), corneal nerve fiber area (CNFA) (P<0.001 for both), corneal nerve fiber width (CNFW) (P=0.046, P=0.027, respectively), and corneal nerve fiber fractal dimension (ACNFrD) (P<0.001 for both). In addition, CNFD and ACNFrD values were significantly lower in the active TAO patients compared with those in the inactive TAO patients (P=0.020, P=0.002, respectively). There were significant correlations between CNFD, CNBD, CNFL, CTBD, CNFA, and ACNFrD and the ocular surface parameters and activity assessment items. CONCLUSIONS Abnormal corneal subbasal nerves were observed in both active and inactive Chinese TAO patients, suggesting that nerve degeneration is associated with the disease. However, the exact underlying mechanisms remain to be elucidated.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Córnea / Oftalmopatía de Graves Tipo de estudio: Observational_studies / Risk_factors_studies Límite: Adult / Female / Humans / Male / Middle aged País/Región como asunto: Asia Idioma: En Revista: Med Sci Monit Asunto de la revista: MEDICINA Año: 2019 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Córnea / Oftalmopatía de Graves Tipo de estudio: Observational_studies / Risk_factors_studies Límite: Adult / Female / Humans / Male / Middle aged País/Región como asunto: Asia Idioma: En Revista: Med Sci Monit Asunto de la revista: MEDICINA Año: 2019 Tipo del documento: Article Pais de publicación: Estados Unidos