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Radiological patterns of pulmonary involvement may predict treatment response in rheumatoid arthritis: A retrospective study.
Hanaka, Tetsuya; Kido, Takashi; Ishimoto, Hiroshi; Oda, Keishi; Noguchi, Shingo; Nawata, Aya; Nakayamada, Shingo; Sakamoto, Noriho; Tanaka, Yoshiya; Yatera, Kazuhiro; Mukae, Hiroshi.
Afiliación
  • Hanaka T; Department of Respiratory Medicine, University of Occupational and Environment Health Japan, 1-1, Iseigaoka, Yahatanishiku, Kitakyushu City, Fukuoka 807-8555, Japan.
  • Kido T; Department of Respiratory Medicine, University of Occupational and Environment Health Japan, 1-1, Iseigaoka, Yahatanishiku, Kitakyushu City, Fukuoka 807-8555, Japan.
  • Ishimoto H; Department of Respiratory Medicine, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1, Sakamoto, Nagasaki City, Nagasaki 852-8501, Japan.
  • Oda K; Department of Respiratory Medicine, University of Occupational and Environment Health Japan, 1-1, Iseigaoka, Yahatanishiku, Kitakyushu City, Fukuoka 807-8555, Japan.
  • Noguchi S; Department of Respiratory Medicine, University of Occupational and Environment Health Japan, 1-1, Iseigaoka, Yahatanishiku, Kitakyushu City, Fukuoka 807-8555, Japan.
  • Nawata A; First Department of Internal Medicine, University of Occupational and Environment Health Japan, 1-1, Iseigaoka, Yahatanishiku, Kitakyushu City, Fukuoka 807-8555, Japan.
  • Nakayamada S; First Department of Internal Medicine, University of Occupational and Environment Health Japan, 1-1, Iseigaoka, Yahatanishiku, Kitakyushu City, Fukuoka 807-8555, Japan.
  • Sakamoto N; Department of Respiratory Medicine, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1, Sakamoto, Nagasaki City, Nagasaki 852-8501, Japan.
  • Tanaka Y; First Department of Internal Medicine, University of Occupational and Environment Health Japan, 1-1, Iseigaoka, Yahatanishiku, Kitakyushu City, Fukuoka 807-8555, Japan.
  • Yatera K; Department of Respiratory Medicine, University of Occupational and Environment Health Japan, 1-1, Iseigaoka, Yahatanishiku, Kitakyushu City, Fukuoka 807-8555, Japan. Electronic address: yatera@med.uoeh-u.ac.jp.
  • Mukae H; Department of Respiratory Medicine, Nagasaki University Graduate School of Biomedical Sciences, 1-7-1, Sakamoto, Nagasaki City, Nagasaki 852-8501, Japan.
Respir Investig ; 57(2): 172-182, 2019 Mar.
Article en En | MEDLINE | ID: mdl-30718103
BACKGROUND: There have been no reports on the relationship between lung radiological patterns and rheumatoid arthritis (RA) disease activity or RA treatment response in patients with RA-associated lung disease (RA-LD). METHODS: Patients with RA-LD who underwent treatment for RA from April 2005 to March 2015 were retrospectively evaluated. RA-LD patients were divided into three groups based on high-resolution computed tomography (HRCT) patterns [usual interstitial pneumonia (UIP), nonspecific interstitial pneumonia (NSIP), and bronchiolitis]. The disease activity score of 28 joints-erythrocyte sedimentation rate (DAS28-ESR) and the response of RA to treatment, as measured by the European League Against Rheumatism (EULAR) response criteria, were investigated. RESULTS: A total of 77 patients (21 with UIP, 23 with NSIP, and 33 with bronchiolitis) were enrolled. Median scores (interquartile range) on the DAS28-ESR at baseline were 5.27 (4.76-5.74), 5.48 (4.24-6.34), and 5.04 (3.90-5.66) for UIP, NSIP, and bronchiolitis, respectively; there were no statistical differences between the three groups (p = 0.412). One year after baseline, 19 (90%), 14 (61%), and 19 (58%) of patients in the UIP, NSIP, and bronchiolitis groups, respectively, were considered good or moderate responders, as evaluated using the EULAR response criteria; there was a significant difference between these three groups (p = 0.014). Multiple logistic regression analysis revealed that the UIP pattern was significantly associated with good or moderate response to RA treatment 1 year after baseline (p = 0.012). CONCLUSIONS: These results suggest that NSIP and bronchiolitis HRCT patterns may be risk factors for resistance to RA therapy.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Artritis Reumatoide / Bronquiolitis / Radiografía Torácica / Intensificación de Imagen Radiográfica / Tomografía Computarizada por Rayos X / Enfermedades Pulmonares Intersticiales / Pulmón Tipo de estudio: Diagnostic_studies / Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Respir Investig Año: 2019 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Países Bajos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Artritis Reumatoide / Bronquiolitis / Radiografía Torácica / Intensificación de Imagen Radiográfica / Tomografía Computarizada por Rayos X / Enfermedades Pulmonares Intersticiales / Pulmón Tipo de estudio: Diagnostic_studies / Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Respir Investig Año: 2019 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Países Bajos