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Levels of anti-Müllerian hormone in premenopausal women with the antiphospholipid syndrome and its association with the risk of clinical complications.
Castillo-Martínez, D; Rivera, V; Mouneu-Ornelas, N; Martínez-Martínez, L A; Jiménez-Rojas, V; Márquez-Velasco, R; Amezcua-Guerra, L M.
Afiliación
  • Castillo-Martínez D; 1 Outpatient Dermatology Clinic, Hospital General de Zona 32, Instituto Mexicano del Seguro Social, Mexico City, Mexico.
  • Rivera V; 2 Department of Rheumatology, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, Mexico.
  • Mouneu-Ornelas N; 2 Department of Rheumatology, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, Mexico.
  • Martínez-Martínez LA; 2 Department of Rheumatology, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, Mexico.
  • Jiménez-Rojas V; 3 Department of Immunology, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, Mexico.
  • Márquez-Velasco R; 3 Department of Immunology, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, Mexico.
  • Amezcua-Guerra LM; 3 Department of Immunology, Instituto Nacional de Cardiología Ignacio Chávez, Mexico City, Mexico.
Lupus ; 28(3): 427-431, 2019 Mar.
Article en En | MEDLINE | ID: mdl-30717622
OBJECTIVE: The study aims to investigate the ovarian reserve in premenopausal women with antiphospholipid syndrome (APS) and to evaluate whether it is associated with cumulative organ damage or the risk of clinical complications. METHODS: This single-center study was conducted in 23 premenopausal female patients (10 with primary APS and 13 with secondary APS) and 24 healthy volunteers. Serum anti-Müllerian hormone (AMH) levels were measured by enzyme-linked immunoassay. Disease-specific organ damage (DIAPS score) and the risk of clinical complications (aGAPSS score) were additionally evaluated in APS patients. RESULTS: Serum AMH levels were similar in APS patients (median 6.06, interquartile range 4.31-7.54 ng/ml) and in controls (4.87, 2.64-6.40 ng/ml; P = 0.116), and no differences were observed between the primary (6.60, 5.49-8.88 ng/ml) and secondary (6.06, 3.91-7.30 ng/ml; P = 0.532) forms of the syndrome. In individuals with APS, serum AMH levels correlated inversely with the aGAPSS score (rho-0.421, 95% confidence intervals -0.716 to -0.001; P = 0.045), while no associations were observed with the DIAPS score (rho-0.001, -0.423 to 0.422; P = 0.996). CONCLUSIONS: Ovarian reserve is not reduced in premenopausal women with APS. In addition, serum AMH levels may reflect the risk of APS-related clinical complications but not the burden of disease-specific organ damage.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Síndrome Antifosfolípido / Reserva Ovárica Tipo de estudio: Etiology_studies / Observational_studies / Risk_factors_studies Límite: Adult / Female / Humans / Middle aged Idioma: En Revista: Lupus Asunto de la revista: REUMATOLOGIA Año: 2019 Tipo del documento: Article País de afiliación: México Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Síndrome Antifosfolípido / Reserva Ovárica Tipo de estudio: Etiology_studies / Observational_studies / Risk_factors_studies Límite: Adult / Female / Humans / Middle aged Idioma: En Revista: Lupus Asunto de la revista: REUMATOLOGIA Año: 2019 Tipo del documento: Article País de afiliación: México Pais de publicación: Reino Unido