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Association of liver and kidney functions with Klotho gene methylation in a population environment exposed to cadmium in China.
Yu, Dongmei; Zhang, Li'e; Yu, Guoqi; Nong, Chuntao; Lei, Mingzhi; Tang, Jiexia; Chen, Quanhui; Cai, Jiangsheng; Chen, Shiyi; Wei, Yi; Xu, Xia; Tang, Xu; Zou, Yunfeng; Qin, Jian.
Afiliación
  • Yu D; Department of Environmental and Occupational Health, Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region, China.
  • Zhang L; Department of Toxicology, School of Public Health, Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region, China.
  • Yu G; Department of Environmental and Occupational Health, Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region, China.
  • Nong C; Department of Environmental and Occupational Health, Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region, China.
  • Lei M; Department of Environmental and Occupational Health, Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region, China.
  • Tang J; Department of Environmental and Occupational Health, Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region, China.
  • Chen Q; Department of Environmental and Occupational Health, Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region, China.
  • Cai J; Department of Environmental and Occupational Health, Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region, China.
  • Wei Y; Department of Environmental and Occupational Health, Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region, China.
  • Xu X; Department of Environmental and Occupational Health, Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region, China.
  • Tang X; Department of Environmental and Occupational Health, Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region, China.
  • Zou Y; Department of Toxicology, School of Public Health, Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region, China.
  • Qin J; Department of Environmental and Occupational Health, Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region, China.
Int J Environ Health Res ; 30(1): 38-48, 2020 Feb.
Article en En | MEDLINE | ID: mdl-30714826
Exposure to the heavy metal cadmium has adverse effects on human health, including DNA methylation. This study aimed to investigate the effects of cadmium on liver and kidney functions and Klotho gene methylation and to explore the relationship of methylation level with indicators of liver and kidney functions. Graphite furnace atomic absorption spectrometry was conducted to determine urinary cadmium, and an automatic biochemical analyzer was used to detect indices of liver and kidney functions. PCR pyrosequencing was performed to detect the methylation rate of Klotho. One-way ANOVA was adopted to compare the differences between groups, and the linear correlation to variables was analyzed. Cadmium exposure was negatively correlated with albumin level (r=-0.143, p=0.021) and positively correlated with urinary ß2-microglobulin level (r=0.229, p<0.001). However, the methylation levels of Klotho gene was decreased and increased by low and high doses of cadmium exposure, respectively. And Klothomethylation levels were negatively correlated with albumin levels and positively correlated with ß2-microglobulin levels.In this study, cadmium exposure affects liver and kidney functions as well as Klotho methylation levels, but the effect on Klotho methylation levels is not linear. Klotho methylation levels also influence liver and kidney functions.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Cadmio / Metilación de ADN / Contaminantes Ambientales / Glucuronidasa / Riñón / Hígado Tipo de estudio: Risk_factors_studies País/Región como asunto: Asia Idioma: En Revista: Int J Environ Health Res Asunto de la revista: SAUDE AMBIENTAL Año: 2020 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Cadmio / Metilación de ADN / Contaminantes Ambientales / Glucuronidasa / Riñón / Hígado Tipo de estudio: Risk_factors_studies País/Región como asunto: Asia Idioma: En Revista: Int J Environ Health Res Asunto de la revista: SAUDE AMBIENTAL Año: 2020 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido