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Neuroimaging in Hereditary Spastic Paraplegias: Current Use and Future Perspectives.
da Graça, Felipe Franco; de Rezende, Thiago Junqueira Ribeiro; Vasconcellos, Luiz Felipe Rocha; Pedroso, José Luiz; Barsottini, Orlando Graziani P; França, Marcondes C.
Afiliación
  • da Graça FF; Department of Neurology and Neuroimaging Laboratory, University of Campinas (UNICAMP), Campinas, Brazil.
  • de Rezende TJR; Department of Neurology and Neuroimaging Laboratory, University of Campinas (UNICAMP), Campinas, Brazil.
  • Vasconcellos LFR; Institute of Neurology, Federal University of Rio de Janeiro (UFRJ), Rio de Janeiro, Brazil.
  • Pedroso JL; Department of Neurology, Federal University of São Paulo (UNIFESP), São Paulo, Brazil.
  • Barsottini OGP; Department of Neurology, Federal University of São Paulo (UNIFESP), São Paulo, Brazil.
  • França MC; Department of Neurology and Neuroimaging Laboratory, University of Campinas (UNICAMP), Campinas, Brazil.
Front Neurol ; 9: 1117, 2018.
Article en En | MEDLINE | ID: mdl-30713518
Hereditary spastic paraplegias (HSP) are a large group of genetic diseases characterized by progressive degeneration of the long tracts of the spinal cord, namely the corticospinal tracts and dorsal columns. Genotypic and phenotypic heterogeneity is a hallmark of this group of diseases, which makes proper diagnosis and management often challenging. In this scenario, magnetic resonance imaging (MRI) emerges as a valuable tool to assist in the exclusion of mimicking disorders and in the detailed phenotypic characterization. Some neuroradiological signs have been reported in specific subtypes of HSP and are therefore helpful to guide genetic testing/interpretation. In addition, advanced MRI techniques enable detection of subtle structural abnormalities not visible on routine scans in the spinal cord and brain of subjects with HSP. In particular, quantitative spinal cord morphometry and diffusion tensor imaging look promising tools to uncover the pathophysiology and to track progression of these diseases. In the current review article, we discuss the current use and future perspectives of MRI in the context of HSP.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Front Neurol Año: 2018 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Front Neurol Año: 2018 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Suiza