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Dengue and chikungunya seroprevalence among Qatari nationals and immigrants residing in Qatar.
Humphrey, John M; Al-Absi, Enas S; Hamdan, Munia M; Okasha, Sara S; Al-Trmanini, Diyna M; El-Dous, Hend G; Dargham, Soha R; Schieffelin, John; Abu-Raddad, Laith J; Nasrallah, Gheyath K.
Afiliación
  • Humphrey JM; Division of Infectious Diseases, Department of Medicine, Indiana University, Indianapolis, IN, United States of America.
  • Al-Absi ES; Department of Biomedical Science, College of Health Sciences, Qatar University, Doha, Qatar.
  • Hamdan MM; BioMedical Research Center, Qatar University, Doha, Qatar.
  • Okasha SS; Department of Biomedical Science, College of Health Sciences, Qatar University, Doha, Qatar.
  • Al-Trmanini DM; BioMedical Research Center, Qatar University, Doha, Qatar.
  • El-Dous HG; Department of Biomedical Science, College of Health Sciences, Qatar University, Doha, Qatar.
  • Dargham SR; BioMedical Research Center, Qatar University, Doha, Qatar.
  • Schieffelin J; Department of Biomedical Science, College of Health Sciences, Qatar University, Doha, Qatar.
  • Abu-Raddad LJ; BioMedical Research Center, Qatar University, Doha, Qatar.
  • Nasrallah GK; Department of Biomedical Science, College of Health Sciences, Qatar University, Doha, Qatar.
PLoS One ; 14(1): e0211574, 2019.
Article en En | MEDLINE | ID: mdl-30703150
The objective of this study is to characterize the seroprevalence of anti-dengue (DENV) and anti-chikungunya (CHIKV) antibodies among blood donors residing in Qatar who are Middle East and North Africa (MENA) nationals and non-nationals. Sera were collected from adult blood donors in Qatar from 2013 to 2016 and tested for anti-DENV and anti-CHIKV IgG using commercial microplate enzyme-linked immunosorbent assays. Age-specific seroprevalence was summarized by region/nationality: Asia (India, Philippines), Middle East (Iran, Jordan, Lebanon, Pakistan, Palestine, Syria, Yemen), North Africa (Egypt, Sudan), Qatar. The adjusted odds of anti-DENV and anti-CHIKV IgG seropositivity was estimated by logistic regression. Among 1,992 serum samples tested, Asian nationals had higher adjusted odds of being seropositive for anti-DENV antibodies compared to nationals of the Middle East (aOR 0.05, 95% CI 0.04-0.07), North Africa (aOR 0.14, 95% CI 0.10-0.20), and Qatar (aOR 0.01, 95% CI 0.01-0.03). Asian nationals also had higher adjusted odds of being seropositive for anti-CHIKV antibodies compared to those from the Middle East (aOR 0.14, 95% CI 0.07-0.27), North Africa (aOR 0.50, 95% CI 0.26-0.96), and Qatar (aOR 0.38, 95% CI 0.15-0.96). The adjusted odds of being anti-DENV seropositive was higher among anti-CHIKV seropositive adults, and vice versa (aOR 1.94, 95% CI 1.09-3.44), suggesting co-circulation of these viruses. DENV and CHIKV exposure is lower in Qatar and MENA nationals compared to Asian nationals suggesting a lower burden of DENV and CHIKV disease in the MENA. Antibodies to both viruses were detected in nationals from most MENA countries, supporting the need to better understand the regional epidemiology of these viruses.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Estudios Seroepidemiológicos / Virus Chikungunya / Dengue / Virus del Dengue / Emigrantes e Inmigrantes / Fiebre Chikungunya / Anticuerpos Antivirales Tipo de estudio: Observational_studies / Prevalence_studies / Risk_factors_studies Límite: Adult / Female / Humans / Male / Middle aged País/Región como asunto: Asia Idioma: En Revista: PLoS One Asunto de la revista: CIENCIA / MEDICINA Año: 2019 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Estudios Seroepidemiológicos / Virus Chikungunya / Dengue / Virus del Dengue / Emigrantes e Inmigrantes / Fiebre Chikungunya / Anticuerpos Antivirales Tipo de estudio: Observational_studies / Prevalence_studies / Risk_factors_studies Límite: Adult / Female / Humans / Male / Middle aged País/Región como asunto: Asia Idioma: En Revista: PLoS One Asunto de la revista: CIENCIA / MEDICINA Año: 2019 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos