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Elevated Platelet Count Appears to Be Causally Associated with Increased Risk of Lung Cancer: A Mendelian Randomization Analysis.
Zhu, Ying; Wei, Yongyue; Zhang, Ruyang; Dong, Xuesi; Shen, Sipeng; Zhao, Yang; Bai, Jianling; Albanes, Demetrius; Caporaso, Neil E; Landi, Maria Teresa; Zhu, Bin; Chanock, Stephen J; Gu, Fangyi; Lam, Stephen; Tsao, Ming-Sound; Shepherd, Frances A; Tardon, Adonina; Fernández-Somoano, Ana; Fernandez-Tardon, Guillermo; Chen, Chu; Barnett, Matthew J; Doherty, Jennifer; Bojesen, Stig E; Johansson, Mattias; Brennan, Paul; McKay, James D; Carreras-Torres, Robert; Muley, Thomas; Risch, Angela; Wichmann, Heunz-Erich; Bickeboeller, Heike; Rosenberger, Albert; Rennert, Gad; Saliba, Walid; Arnold, Susanne M; Field, John K; Davies, Michael P A; Marcus, Michael W; Wu, Xifeng; Ye, Yuanqing; Le Marchand, Loic; Wilkens, Lynne R; Melander, Olle; Manjer, Jonas; Brunnström, Hans; Hung, Rayjean J; Liu, Geoffrey; Brhane, Yonathan; Kachuri, Linda; Andrew, Angeline S.
Afiliación
  • Zhu Y; Department of Biostatistics, School of Public Health, Nanjing Medical University, Nanjing, China.
  • Wei Y; Department of Biostatistics, School of Public Health, Nanjing Medical University, Nanjing, China.
  • Zhang R; Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts.
  • Dong X; China International Cooperation Center (CICC) for Environment and Human Health, Nanjing Medical University, Nanjing, China.
  • Shen S; Department of Biostatistics, School of Public Health, Nanjing Medical University, Nanjing, China.
  • Zhao Y; Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts.
  • Bai J; China International Cooperation Center (CICC) for Environment and Human Health, Nanjing Medical University, Nanjing, China.
  • Albanes D; Department of Epidemiology and Biostatistics, School of Public Health, Southeast University, Nanjing, China.
  • Caporaso NE; Department of Environmental Health, Harvard School of Public Health, Boston, Massachusetts.
  • Landi MT; Department of Biostatistics, School of Public Health, Nanjing Medical University, Nanjing, China.
  • Zhu B; China International Cooperation Center (CICC) for Environment and Human Health, Nanjing Medical University, Nanjing, China.
  • Chanock SJ; Department of Biostatistics, School of Public Health, Nanjing Medical University, Nanjing, China.
  • Gu F; Division of Cancer Epidemiology and Genetics, NCI, NIH, Bethesda, Maryland.
  • Lam S; Division of Cancer Epidemiology and Genetics, NCI, NIH, Bethesda, Maryland.
  • Tsao MS; Division of Cancer Epidemiology and Genetics, NCI, NIH, Bethesda, Maryland.
  • Shepherd FA; Division of Cancer Epidemiology and Genetics, NCI, NIH, Bethesda, Maryland.
  • Tardon A; Division of Cancer Epidemiology and Genetics, NCI, NIH, Bethesda, Maryland.
  • Fernández-Somoano A; Department of Cancer Prevention and Control, Roswell Park Comprehensive Cancer Center, Buffalo, New York.
  • Fernandez-Tardon G; British Columbia Cancer Agency, Vancouver, British Columbia, Canada.
  • Chen C; University Health Network, Princess Margaret Cancer Centre, Toronto, Ontario, Canada.
  • Barnett MJ; University Health Network, Princess Margaret Cancer Centre, Toronto, Ontario, Canada.
  • Doherty J; University of Oviedo and CIBERESP, Faculty of Medicine, Oviedo, Spain.
  • Bojesen SE; University of Oviedo and CIBERESP, Faculty of Medicine, Oviedo, Spain.
  • Johansson M; University of Oviedo and CIBERESP, Faculty of Medicine, Oviedo, Spain.
  • Brennan P; Program in Epidemiology, Fred Hutchinson Cancer Research Center, Seattle, Washington.
  • McKay JD; Program in Epidemiology, Fred Hutchinson Cancer Research Center, Seattle, Washington.
  • Carreras-Torres R; Program in Epidemiology, Fred Hutchinson Cancer Research Center, Seattle, Washington.
  • Muley T; Department of Clinical Biochemistry, Herlev and Gentofte Hospital, Copenhagen University Hospital, Copenhagen, Denmark.
  • Risch A; Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark.
  • Wichmann HE; Copenhagen General Population Study, Herlev and Gentofte Hospital, Copenhagen, Denmark.
  • Bickeboeller H; International Agency for Research on Cancer, World Health Organization, Lyon, France.
  • Rosenberger A; International Agency for Research on Cancer, World Health Organization, Lyon, France.
  • Rennert G; International Agency for Research on Cancer, World Health Organization, Lyon, France.
  • Saliba W; International Agency for Research on Cancer, World Health Organization, Lyon, France.
  • Arnold SM; Thoraxklinik at University Hospital Heidelberg, Heidelberg, Germany.
  • Field JK; Translational Lung Research Center Heidelberg (TLRC-H), Heidelberg, Germany.
  • Davies MPA; Translational Lung Research Center Heidelberg (TLRC-H), Heidelberg, Germany.
  • Marcus MW; German Center for Lung Research (DZL), Heidelberg, Germany.
  • Wu X; University of Salzburg and Cancer Cluster Salzburg, Salzburg, Austria.
  • Ye Y; Research Unit of Molecular Epidemiology, Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, Germany.
  • Le Marchand L; Department of Genetic Epidemiology, University Medical Center, Georg-August-University Göttingen, Germany.
  • Wilkens LR; Department of Genetic Epidemiology, University Medical Center, Georg-August-University Göttingen, Germany.
  • Melander O; Department of Community Medicine and Epidemiology, Clalit National Cancer Control Center at Carmel Medical Center and Technion Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel.
  • Manjer J; Department of Community Medicine and Epidemiology, Clalit National Cancer Control Center at Carmel Medical Center and Technion Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel.
  • Brunnström H; Markey Cancer Center, University of Kentucky, Lexington, Kentucky.
  • Hung RJ; Institute of Translational Medicine, University of Liverpool, Liverpool, United Kingdom.
  • Liu G; Institute of Translational Medicine, University of Liverpool, Liverpool, United Kingdom.
  • Brhane Y; Institute of Translational Medicine, University of Liverpool, Liverpool, United Kingdom.
  • Kachuri L; Department of Epidemiology, University of Texas MD Anderson Cancer Center, Houston, Texas.
  • Andrew AS; Department of Epidemiology, University of Texas MD Anderson Cancer Center, Houston, Texas.
Cancer Epidemiol Biomarkers Prev ; 28(5): 935-942, 2019 05.
Article en En | MEDLINE | ID: mdl-30700444
BACKGROUND: Platelets are a critical element in coagulation and inflammation, and activated platelets are linked to cancer risk through diverse mechanisms. However, a causal relationship between platelets and risk of lung cancer remains unclear. METHODS: We performed single and combined multiple instrumental variable Mendelian randomization analysis by an inverse-weighted method, in addition to a series of sensitivity analyses. Summary data for associations between SNPs and platelet count are from a recent publication that included 48,666 Caucasian Europeans, and the International Lung Cancer Consortium and Transdisciplinary Research in Cancer of the Lung data consisting of 29,266 cases and 56,450 controls to analyze associations between candidate SNPs and lung cancer risk. RESULTS: Multiple instrumental variable analysis incorporating six SNPs showed a 62% increased risk of overall non-small cell lung cancer [NSCLC; OR, 1.62; 95% confidence interval (CI), 1.15-2.27; P = 0.005] and a 200% increased risk for small-cell lung cancer (OR, 3.00; 95% CI, 1.27-7.06; P = 0.01). Results showed only a trending association with NSCLC histologic subtypes, which may be due to insufficient sample size and/or weak effect size. A series of sensitivity analysis retained these findings. CONCLUSIONS: Our findings suggest a causal relationship between elevated platelet count and increased risk of lung cancer and provide evidence of possible antiplatelet interventions for lung cancer prevention. IMPACT: These findings provide a better understanding of lung cancer etiology and potential evidence for antiplatelet interventions for lung cancer prevention.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Plaquetas / Carcinoma de Células Escamosas / Carcinoma de Pulmón de Células no Pequeñas / Carcinoma Pulmonar de Células Pequeñas / Adenocarcinoma del Pulmón / Neoplasias Pulmonares Tipo de estudio: Clinical_trials / Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: Cancer Epidemiol Biomarkers Prev Asunto de la revista: BIOQUIMICA / EPIDEMIOLOGIA / NEOPLASIAS Año: 2019 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Plaquetas / Carcinoma de Células Escamosas / Carcinoma de Pulmón de Células no Pequeñas / Carcinoma Pulmonar de Células Pequeñas / Adenocarcinoma del Pulmón / Neoplasias Pulmonares Tipo de estudio: Clinical_trials / Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: Cancer Epidemiol Biomarkers Prev Asunto de la revista: BIOQUIMICA / EPIDEMIOLOGIA / NEOPLASIAS Año: 2019 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos