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Wnt/Fgf crosstalk is required for the specification of basal cells in the mouse trachea.
Hou, Zhili; Wu, Qi; Sun, Xin; Chen, Huaiyong; Li, Yu; Zhang, Yongchun; Mori, Munemasa; Yang, Ying; Que, Jianwen; Jiang, Ming.
Afiliación
  • Hou Z; Center for Human Development, Department of Medicine, Columbia University Medical Center, NY 10032, USA.
  • Wu Q; Tianjin Haihe Hospital, Tianjin 300350, P.R. China.
  • Sun X; Haihe Clinical College of Tianjin Medical University, Tianjin 301700, P.R. China.
  • Chen H; Tianjin Haihe Hospital, Tianjin 300350, P.R. China.
  • Li Y; Tianjin Haihe Hospital, Tianjin 300350, P.R. China.
  • Zhang Y; Tianjin Haihe Hospital, Tianjin 300350, P.R. China.
  • Mori M; Center for Human Development, Department of Medicine, Columbia University Medical Center, NY 10032, USA.
  • Yang Y; Tianjin Haihe Hospital, Tianjin 300350, P.R. China.
  • Que J; Center for Human Development, Department of Medicine, Columbia University Medical Center, NY 10032, USA.
  • Jiang M; Center for Human Development, Department of Medicine, Columbia University Medical Center, NY 10032, USA.
Development ; 146(3)2019 02 11.
Article en En | MEDLINE | ID: mdl-30696710
Basal progenitor cells are crucial for the establishment and maintenance of the tracheal epithelium. However, it remains unclear how these progenitor cells are specified during foregut development. Here, we found that ablation of the Wnt chaperone protein Gpr177 (also known as Wntless) in mouse tracheal epithelium causes a significant reduction in the number of basal progenitor cells accompanied by cartilage loss in Shh-Cre;Gpr177loxp/loxp mutants. Consistent with the association between cartilage and basal cell development, Nkx2.1+p63+ basal cells are co-present with cartilage nodules in Shh-Cre;Ctnnb1DM/loxp mutants, which maintain partial cell-cell adhesion but not the transcription regulation function of ß-catenin. More importantly, deletion of Ctnnb1 in the mesenchyme leads to the loss of basal cells and cartilage, concomitant with reduced transcript levels of Fgf10 in Dermo1-Cre;Ctnnb1loxp/loxp mutants. Furthermore, deletion of Fgf receptor 2 (Fgfr2) in the epithelium also leads to significantly reduced numbers of basal cells, supporting the importance of Wnt/Fgf crosstalk in early tracheal development.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Tráquea / Mucosa Respiratoria / Receptor Tipo 2 de Factor de Crecimiento de Fibroblastos / Factor 10 de Crecimiento de Fibroblastos / Vía de Señalización Wnt Límite: Animals Idioma: En Revista: Development Asunto de la revista: BIOLOGIA / EMBRIOLOGIA Año: 2019 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Tráquea / Mucosa Respiratoria / Receptor Tipo 2 de Factor de Crecimiento de Fibroblastos / Factor 10 de Crecimiento de Fibroblastos / Vía de Señalización Wnt Límite: Animals Idioma: En Revista: Development Asunto de la revista: BIOLOGIA / EMBRIOLOGIA Año: 2019 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Reino Unido