Your browser doesn't support javascript.
loading
Stage-matched survival differences by ethnicity among gastric cancer patients of Asian ancestry treated in the United States.
Rhome, Ryan M; Ru, Meng; Moshier, Erin; Mazumdar, Madhu; Buckstein, Michael H.
Afiliación
  • Rhome RM; Department of Radiation Oncology, Indiana University, Indianapolis, Indiana.
  • Ru M; Department of Population Health Science and Policy, Icahn School of Medicine at Mount Sinai, New York, New York.
  • Moshier E; Department of Population Health Science and Policy, Icahn School of Medicine at Mount Sinai, New York, New York.
  • Mazumdar M; Department of Population Health Science and Policy, Icahn School of Medicine at Mount Sinai, New York, New York.
  • Buckstein MH; Department of Radiation Oncology, Icahn School of Medicine at Mount Sinai, New York, New York.
J Surg Oncol ; 119(6): 737-748, 2019 May.
Article en En | MEDLINE | ID: mdl-30694524
BACKGROUND: Differences have been noted in overall survival (OS) in gastric cancer (GC) between trials conducted in Western vs Asian countries. The National Cancer Database (NCDB) reports outcomes and patient/disease variables relevant to OS. METHODS: Using NCDB, we identified 89 558 adult patients with GC diagnosed (2004-2012), where self-reported race/ethnicity was available. Cox proportional hazard model was used to calculate multivariable hazard ratio (HR) of death, adjusting for race/ethnicity, age, gender, insurance, histology, grade, location, stage, and treatment type. RESULTS: After adjustment, Asian patients had improved OS (HR = 0.74, 95% confidence intervals [CI] = 0.71-0.77). There were differences in OS between Asian ethnicities compared with white patients (n = 69 945), notably with Korean (n = 1249, HR = 0.70, 95% CI = 0.64-0.75), Chinese (n = 1271, HR = 0.69, 95% CI = 0.64-0.75), and Indian/Pakistani patients (n = 492, HR = 0.68, 95% CI = 0.61-0.76). Japanese (n = 829, HR = 0.84, 95% CI = 0.77-0.91) and Vietnamese (n = 560, HR = 0.79, 95% CI = 0.71-0.88) OS was also improved (P < 0.0001), while Filipino patients showed no difference (n = 415, HR = 1.00). Black patients had slightly improved OS (n = 13 500, HR = 0.98, 95% CI = 0.95-1.00, P = 0.035). CONCLUSIONS: This analysis supports improved OS in Asian patients independent of stage, treatment, and known patient or disease characteristics in this large US cohort, and is the largest to define OS differences between Asian ethnicities.
Asunto(s)
Palabras clave
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Gástricas / Asiático Tipo de estudio: Prognostic_studies Aspecto: Determinantes_sociais_saude Límite: Female / Humans / Male / Middle aged País/Región como asunto: America do norte Idioma: En Revista: J Surg Oncol Año: 2019 Tipo del documento: Article Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Gástricas / Asiático Tipo de estudio: Prognostic_studies Aspecto: Determinantes_sociais_saude Límite: Female / Humans / Male / Middle aged País/Región como asunto: America do norte Idioma: En Revista: J Surg Oncol Año: 2019 Tipo del documento: Article Pais de publicación: Estados Unidos