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Decreased IL-17RB expression impairs CD11b+CD11c- myeloid cell accumulation in gastric mucosa and host defense during the early-phase of Helicobacter pylori infection.
Teng, Yong-Sheng; Liu, Yu-Gang; Chen, Xian-Hua; Wang, Ting-Ting; Cheng, Ping; Lv, Yi-Pin; Kong, Hui; Mao, Fang-Yuan; Hao, Chuan-Jie; Yang, Shi-Ming; Chen, Weisan; Zhang, Jin-Yu; Peng, Liu-Sheng; Han, Bin; Ma, Qiang; Han, Jia; Zou, Quan-Ming; Zhuang, Yuan.
Afiliación
  • Teng YS; National Engineering Research Centre of Immunological Products, Department of Microbiology and Biochemical Pharmacy, College of Pharmacy and Laboratory Medicine, Third Military Medical University, Chongqing, China.
  • Liu YG; National Engineering Research Centre of Immunological Products, Department of Microbiology and Biochemical Pharmacy, College of Pharmacy and Laboratory Medicine, Third Military Medical University, Chongqing, China.
  • Chen XH; Diagnosis and Treatment Center for Servicemen, Southwest Hospital, Third Military Medical University, Chongqing, China.
  • Wang TT; National Engineering Research Centre of Immunological Products, Department of Microbiology and Biochemical Pharmacy, College of Pharmacy and Laboratory Medicine, Third Military Medical University, Chongqing, China.
  • Cheng P; National Engineering Research Centre of Immunological Products, Department of Microbiology and Biochemical Pharmacy, College of Pharmacy and Laboratory Medicine, Third Military Medical University, Chongqing, China.
  • Lv YP; National Engineering Research Centre of Immunological Products, Department of Microbiology and Biochemical Pharmacy, College of Pharmacy and Laboratory Medicine, Third Military Medical University, Chongqing, China.
  • Kong H; National Engineering Research Centre of Immunological Products, Department of Microbiology and Biochemical Pharmacy, College of Pharmacy and Laboratory Medicine, Third Military Medical University, Chongqing, China.
  • Mao FY; National Engineering Research Centre of Immunological Products, Department of Microbiology and Biochemical Pharmacy, College of Pharmacy and Laboratory Medicine, Third Military Medical University, Chongqing, China.
  • Hao CJ; National Engineering Research Centre of Immunological Products, Department of Microbiology and Biochemical Pharmacy, College of Pharmacy and Laboratory Medicine, Third Military Medical University, Chongqing, China.
  • Yang SM; Department of Gastroenterology, XinQiao Hospital, Third Military Medical University, Chongqing, China.
  • Chen W; La Trobe Institute of Molecular Science, La Trobe University, Bundoora, VIC, 3085, Australia.
  • Zhang JY; National Engineering Research Centre of Immunological Products, Department of Microbiology and Biochemical Pharmacy, College of Pharmacy and Laboratory Medicine, Third Military Medical University, Chongqing, China.
  • Peng LS; National Engineering Research Centre of Immunological Products, Department of Microbiology and Biochemical Pharmacy, College of Pharmacy and Laboratory Medicine, Third Military Medical University, Chongqing, China.
  • Han B; Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan Province, China.
  • Ma Q; Affiliated Hospital of North Sichuan Medical College, Nanchong, Sichuan Province, China.
  • Han J; Department of General Surgery, Dianjiang County Hospital of Traditional Chinese Medicine, Chongqing, 408300, China. 1270520740@qq.com.
  • Zou QM; National Engineering Research Centre of Immunological Products, Department of Microbiology and Biochemical Pharmacy, College of Pharmacy and Laboratory Medicine, Third Military Medical University, Chongqing, China. qmzou@tmmu.edu.cn.
  • Zhuang Y; National Engineering Research Centre of Immunological Products, Department of Microbiology and Biochemical Pharmacy, College of Pharmacy and Laboratory Medicine, Third Military Medical University, Chongqing, China. yuanzhuang1983@yahoo.com.
Cell Death Dis ; 10(2): 79, 2019 01 28.
Article en En | MEDLINE | ID: mdl-30692510
Interleukin-17 receptor B (IL-17RB), a member of the IL-17 receptor family activated by IL-17B/IL-17E, has been shown to be involved in inflammatory diseases. However, the regulation and function of IL-17RB in Helicobacter pylori (H. pylori) infection, especially in the early-phase is still unknown. Here, we found that gastric IL-17RB mRNA and protein were decreased in gastric mucosa of both patients and mice infected with H. pylori. In vitro experiments show that IL-17RB expression was down regulated via PI3K/AKT pathway on gastric epithelial cells (GECs) stimulated with H. pylori in a cagA-involved manner, while in vivo studies showed that the effect was partially dependent on cagA expression. IL-17E was also decreased during the early-phase of H. pylori infection, and provision of exogenous IL-17E resulted in increased CD11b+CD11c- myeloid cells accumulation and decreased bacteria colonization within the gastric mucosa. In the early-phase of H. pylori infection, IL-17E-IL-17RB promoted gastric epithelial cell-derived CXCL1/2/5/6 to attract CD11b+CD11c- myeloid cells, and also contributed to host defense by promoting the production of antibacterial protein Reg3a. This study defines a negative regulatory network involving IL-17E, GECs, IL-17RB, CD11b+CD11c- myeloid cells, and Reg3a in the early-phase of H. pylori infection, which results in an impaired host defense within the gastric microenvironment, suggesting IL-17RB as a potential early intervening target in H. pylori infection.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Helicobacter pylori / Infecciones por Helicobacter / Células Mieloides / Antígeno CD11b / Antígeno CD11c / Receptores de Interleucina-17 / Mucosa Gástrica Límite: Animals / Humans Idioma: En Revista: Cell Death Dis Año: 2019 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Helicobacter pylori / Infecciones por Helicobacter / Células Mieloides / Antígeno CD11b / Antígeno CD11c / Receptores de Interleucina-17 / Mucosa Gástrica Límite: Animals / Humans Idioma: En Revista: Cell Death Dis Año: 2019 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido