Physical exercises decreases thrombus and neointima formation in atherosclerotic mice.
Thromb Res
; 175: 21-31, 2019 Mar.
Article
en En
| MEDLINE
| ID: mdl-30685522
The practice of physical exercise is highly indicated to prevent cardiovascular diseases and is directly related to the improvement of endothelial function and the regulation of arterial blood pressure. The objective of this study was to analyze the effect of physical exercise in vascular remodeling after FeCl3 chemically induced arterial injury on atherosclerotic mice. To analyze the effect of exercises on thrombus formation, LDL receptor-deficient mice were fed for 6â¯weeks with a high-fat diet and performed or not physical exercises for 2â¯weeks before the arterial injury. To verify endothelium recovery the animals were exercised or not 2â¯weeks before the injury, and 3â¯weeks after it, when the vessels were analyzed. In this work, we observed that physical exercises done only before arterial injury reduced thrombosis time, protected the endothelial layer, promoted the recruitment of CD34 positive progenitor cells, increased the level of eNOS and gelatinases activities and decreased the number of inflammatory cells in the vessel, but do not avoid the growth of neointima. Otherwise exercises done before and continued after injury, increased gelatinase activities, reduced lipid deposition in the aortic arch and prevented neointima formation. Thus, we could conclude that physical exercises are done before and continued after endothelial injury stimulate endothelial recovery by promoting endothelial cell growth, matrix remodeling and decreasing inflammation in the vessel wall.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Trombosis
/
Ejercicio Físico
/
Aterosclerosis
/
Neointima
/
Remodelación Vascular
Límite:
Animals
/
Humans
/
Male
Idioma:
En
Revista:
Thromb Res
Año:
2019
Tipo del documento:
Article
País de afiliación:
Brasil
Pais de publicación:
Estados Unidos