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A Highly Efficient Tumor-Targeting Nanoprobe with a Novel Cell Membrane Permeability Mechanism.
Lei, Zhendong; Ding, Lin; Yao, Chenjie; Mo, Fengfeng; Li, Chenchen; Huang, Yanan; Yin, Xuelian; Li, Min; Liu, Jinliang; Zhang, Yong; Ling, Changquan; Wang, Yanli.
Afiliación
  • Lei Z; Institute of Nanochemistry and Nanobiology, Shanghai University, Shanghai, 200444, P. R. China.
  • Ding L; Department of Biomedical Engineering, National University of Singapore, Singapore, 119077, Singapore.
  • Yao C; Institute of Nanochemistry and Nanobiology, Shanghai University, Shanghai, 200444, P. R. China.
  • Mo F; Institute of Nanochemistry and Nanobiology, Shanghai University, Shanghai, 200444, P. R. China.
  • Li C; Program in Molecular and Integrative Physiological Sciences, Harvard T.H. Chan School of Public Health, Harvard University, Boston, MA, 02115, USA.
  • Huang Y; Ship Hygiene Department, Faculty of Naval Medicine, Second Military Medical University, Shanghai, 200433, P. R. China.
  • Yin X; Institute of Nanochemistry and Nanobiology, Shanghai University, Shanghai, 200444, P. R. China.
  • Li M; Institute of Nanochemistry and Nanobiology, Shanghai University, Shanghai, 200444, P. R. China.
  • Liu J; Institute of Nanochemistry and Nanobiology, Shanghai University, Shanghai, 200444, P. R. China.
  • Zhang Y; Ship Hygiene Department, Faculty of Naval Medicine, Second Military Medical University, Shanghai, 200433, P. R. China.
  • Ling C; Institute of Nanochemistry and Nanobiology, Shanghai University, Shanghai, 200444, P. R. China.
  • Wang Y; Institute of Nanochemistry and Nanobiology, Shanghai University, Shanghai, 200444, P. R. China.
Adv Mater ; 31(12): e1807456, 2019 Mar.
Article en En | MEDLINE | ID: mdl-30680812
Efficient tumor targeting has been a great challenge in the clinic for a very long time. The traditional targeting methods based on enhanced permeability and retention (EPR) effects show only an ≈5% targeting rate. To solve this problem, a new graphene-based tumor cell nuclear targeting fluorescent nanoprobe (GTTN), with a new tumor-targeting mechanism, is developed. GTTN is a graphene-like single-crystalline structure amphiphilic fluorescent probe with a periphery that is functionalized by sulfonic and hydroxyl groups. This probe has the characteristic of specific tumor cell targeting, as it can directly cross the cell membrane and specifically target to the tumor cell nucleus by the changed permeability of the tumor cell membranes in the tumor tissue. This new targeting mechanism is named the cell membrane permeability targeting (CMPT) mechanism, which is very different from the EPR effect. These probes can recognize tumor tissue at a very early stage and track the invasion and metastasis of tumor cells at the single cell level. The tumor-targeting rate is improved from less than 5% to more than 50%. This achievement in efficient and accurate tumor cell targeting will speed up the arrival of a new era of tumor diagnosis and treatment.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Permeabilidad de la Membrana Celular / Nanopartículas / Colorantes Fluorescentes / Grafito / Neoplasias Límite: Animals / Female / Humans Idioma: En Revista: Adv Mater Asunto de la revista: BIOFISICA / QUIMICA Año: 2019 Tipo del documento: Article Pais de publicación: Alemania
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Permeabilidad de la Membrana Celular / Nanopartículas / Colorantes Fluorescentes / Grafito / Neoplasias Límite: Animals / Female / Humans Idioma: En Revista: Adv Mater Asunto de la revista: BIOFISICA / QUIMICA Año: 2019 Tipo del documento: Article Pais de publicación: Alemania