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Clinical Considerations Regarding the Use of Obesity Pharmacotherapy in Adolescents with Obesity.
Srivastava, Gitanjali; Fox, Claudia K; Kelly, Aaron S; Jastreboff, Ania M; Browne, Allen F; Browne, Nancy T; Pratt, Janey S A; Bolling, Christopher; Michalsky, Marc P; Cook, Stephen; Lenders, Carine M; Apovian, Caroline M.
Afiliación
  • Srivastava G; Department of Medicine, Section of Endocrinology, Diabetes, Nutrition and Weight Management, Boston University School of Medicine and Boston Medical Center, Boston, Massachusetts, USA.
  • Fox CK; Department of Pediatrics, Center for Pediatric Obesity Medicine, University of Minnesota Medical School, Minneapolis, Minnesota, USA.
  • Kelly AS; Department of Pediatrics, Center for Pediatric Obesity Medicine, University of Minnesota Medical School, Minneapolis, Minnesota, USA.
  • Jastreboff AM; Department of Internal Medicine, Section of Endocrinology and Metabolism and Department of Pediatrics, Section of Pediatric Endocrinology, Yale University School of Medicine, New Haven, Connecticut, USA.
  • Browne AF; Department of Surgery, Maine Medical Center, Portland, Maine, USA.
  • Browne NT; Department of Pediatrics, Eastern Maine Medical Center, Bangor, Maine, USA.
  • Pratt JSA; Department of Surgery, Stanford University School of Medicine, Stanford, California, USA.
  • Bolling C; Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.
  • Michalsky MP; Department of Pediatric Surgery, Nationwide Children's Hospital and The Ohio State University, College of Medicine, Columbus, Ohio, USA.
  • Cook S; Department of Pediatrics, Medicine & Center for Community Health, University of Rochester School of Medicine, Golisano's Children's Hospital, Rochester, New York, USA.
  • Lenders CM; Department of Pediatrics, Pediatric Nutrition and Fitness for Life, Boston University School of Medicine and Boston Medical Center, Boston, Massachusetts, USA.
  • Apovian CM; Department of Medicine, Section of Endocrinology, Diabetes, Nutrition and Weight Management, Boston University School of Medicine and Boston Medical Center, Boston, Massachusetts, USA.
Obesity (Silver Spring) ; 27(2): 190-204, 2019 02.
Article en En | MEDLINE | ID: mdl-30677262
A growing number of youth suffer from obesity and in particular severe obesity for which intensive lifestyle intervention does not adequately reduce excess adiposity. A treatment gap exists wherein effective treatment options for an adolescent with severe obesity include intensive lifestyle modification or metabolic and bariatric surgery while the application of obesity pharmacotherapy remains largely underutilized. These youth often present with numerous obesity-related comorbid diseases, including hypertension, dyslipidemia, prediabetes/type 2 diabetes, obstructive sleep apnea, nonalcoholic fatty liver disease, musculoskeletal problems, and psychosocial issues such as depression, anxiety, and social stigmatization. Current pediatric obesity treatment algorithms for pediatric primary care providers focus primarily on intensive lifestyle intervention with escalation of treatment intensity through four stages of intervention. Although a recent surge in the number of Food and Drug Administration-approved medications for obesity treatment has emerged in adults, pharmacotherapy options for youth remain limited. Recognizing treatment and knowledge gaps related to pharmacological agents and the urgent need for more effective treatment strategies in this population, discussed here are the efficacy, safety, and clinical application of obesity pharmacotherapy in youth with obesity based on current literature. Legal ramifications, informed consent regulations, and appropriate off-label use of these medications in pediatrics are included, focusing on prescribing practices and prescriber limits.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Obesidad Infantil Límite: Adolescent / Child / Humans Idioma: En Revista: Obesity (Silver Spring) Asunto de la revista: CIENCIAS DA NUTRICAO / FISIOLOGIA / METABOLISMO Año: 2019 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Obesidad Infantil Límite: Adolescent / Child / Humans Idioma: En Revista: Obesity (Silver Spring) Asunto de la revista: CIENCIAS DA NUTRICAO / FISIOLOGIA / METABOLISMO Año: 2019 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos