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Elevated Microdamage Spatially Correlates with Stress in Metastatic Vertebrae.
Atkins, Ayelet; Burke, Mikhail; Samiezadeh, Saeid; Akens, Margarete K; Hardisty, Michael; Whyne, Cari M.
Afiliación
  • Atkins A; Orthopaedics Biomechanics Laboratory, Sunnybrook Research Institute, Toronto, ON, Canada.
  • Burke M; Orthopaedics Biomechanics Laboratory, Sunnybrook Research Institute, Toronto, ON, Canada.
  • Samiezadeh S; Institute of Biomaterials and Biomedical Engineering, University of Toronto, Toronto, ON, Canada.
  • Akens MK; Orthopaedics Biomechanics Laboratory, Sunnybrook Research Institute, Toronto, ON, Canada.
  • Hardisty M; Division of Orthopaedics, Department of Surgery, University of Toronto, Toronto, ON, Canada.
  • Whyne CM; Techna Institute, University Health Network, Toronto, ON, Canada.
Ann Biomed Eng ; 47(4): 980-989, 2019 Apr.
Article en En | MEDLINE | ID: mdl-30673956
Metastasis of cancer to the spine impacts bone quality. This study aims to characterize vertebral microdamage secondary to metastatic disease considering the pattern of damage and its relationship to stress and strain under load. Osteolytic and mixed osteolytic/osteoblastic vertebral metastases were produced in athymic rats via HeLa cervical or canine Ace-1 prostate cancer cell inoculation, respectively. After 21 days, excised motion segments (T12-L2) were µCT scanned, stained with BaSO4 and re-imaged. T13-L2 motion segments were loaded in axial compression to induce microdamage, re-stained and re-imaged. L1 (loaded) and T12 (unloaded) vertebrae were fixed, sample blocks cut, polished and BSE imaged. µFE models were generated of all L1 vertebrae with displacement boundary conditions applied based on the loaded µCT images. µCT stereological analysis, BSE analysis and µFE derived von Mises stress and principal strains were quantitatively compared (ANOVA), spatial correlations determined and patterns of microdamage assessed qualitatively. BaSO4 identified microdamage was found to be spatially correlated with regions of high stress in µFEA. Load-induced microdamage was shown to be elevated in the presence of osteolytic and mixed metastatic disease, with diffuse, crossed hatched areas of microdamage present in addition to linear microdamage and microfractures in metastatic tissue, suggesting diminished bone quality.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Columna Vertebral / Fracturas por Estrés / Fracturas de la Columna Vertebral / Vértebras Lumbares Límite: Animals Idioma: En Revista: Ann Biomed Eng Año: 2019 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Columna Vertebral / Fracturas por Estrés / Fracturas de la Columna Vertebral / Vértebras Lumbares Límite: Animals Idioma: En Revista: Ann Biomed Eng Año: 2019 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Estados Unidos