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Is it possible to predict late antepartum stillbirth by means of cerebroplacental ratio and maternal characteristics?
Morales-Roselló, José; Galindo, Alberto; Herraiz, Ignacio; Gil, María M; Brik, Maia; De Paco-Matallana, Catalina; Ciammela, Ricardo; Sanchez Ajenjo, Carlos; Cañada Martinez, Antonio José; Delgado, Juan Luis; Perales-Marín, Alfredo.
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  • Morales-Roselló J; Servicio de Obstetricia y Ginecología, Hospital Universitario y Politécnico La Fe, Valencia, Spain.
  • Galindo A; Department of Pediatrics, Obstetrics and Gynecology, Universidad de Valencia, Valencia, Spain.
  • Herraiz I; Fetal Medicine Unit, Department of Obstetrics and Gynecology, Maternal and Child Health and Development Network, University Hospital 12 de Octubre, 12 de Octubre Research Institute (imas12). Universidad Complutense de Madrid, Madrid, Spain.
  • Gil MM; Fetal Medicine Unit, Department of Obstetrics and Gynecology, Maternal and Child Health and Development Network, University Hospital 12 de Octubre, 12 de Octubre Research Institute (imas12). Universidad Complutense de Madrid, Madrid, Spain.
  • Brik M; Department of Obstetrics and Gynecology, Servicio de Obstetricia y Ginecología, Hospital Universitario de Torrejón, Madrid, Spain.
  • De Paco-Matallana C; Department of Obstetrics and Gynecology, Universidad Francisco de Vitoria, Madrid, Spain.
  • Ciammela R; Department of Obstetrics and Gynecology, Servicio de Obstetricia y Ginecología, Hospital Universitario de Torrejón, Madrid, Spain.
  • Sanchez Ajenjo C; Department of Obstetrics and Gynecology, Universidad Francisco de Vitoria, Madrid, Spain.
  • Cañada Martinez AJ; Servicio de Obstetricia y Ginecología, Hospital Universitario Virgen de la Arrixaca, Murcia, Spain.
  • Delgado JL; Department of Obstetrics and Gynecology, Universidad de Murcia, Murcia, Spain.
  • Perales-Marín A; Servicio de Obstetricia y Ginecología, Hospital Universitario y Politécnico La Fe, Valencia, Spain.
J Matern Fetal Neonatal Med ; 33(17): 2996-3002, 2020 Sep.
Article en En | MEDLINE | ID: mdl-30672365
Objective: To examine the potential value of fetal ultrasound and maternal characteristics in the prediction of antepartum stillbirth after 32 weeks' gestation.Methods: This was a retrospective multicenter study in Spain. In 29 pregnancies, umbilical artery pulsatility index (UA PI), middle cerebral artery pulsatility index (MCA PI), cerebroplacental ratio (CPR), estimated fetal weight (EFW), and maternal characteristics were recorded within 15 days prior to a stillbirth. The values of UA PI, MCA PI, and CPR were converted into multiples of the normal median (MoM) for gestational age and the EFW was expressed as percentile according to a Spanish reference range for gestational age. Data from the 29 pregnancies with stillbirths and 2298 control pregnancies resulting in livebirths were compared and multivariate logistic regression analysis was used to determine significant predictors of stillbirth.Results: The only significant predictor of stillbirth was CPR (OR = 0.161, 95% confidence interval [CI] 0.035, 0.654; p = .014); the area under the receiver operating characteristics curve was 0.663 (95% CI 0.545, 0.782) and the detection rate (DR) was 32.14% at a 10% false-positive rate (FPR). In addition, when we included MCA and UA PI MoM instead of CPR, only MCA PI MoM was significant (OR = 0.104, 95% confidence interval [CI] 0.013, 0.735; p = .029), with similar prediction abilities (area under the curve (AUC) 0.645, DR 28.6%, FPR 10%).Conclusions: The CPR and MCA PI are predictors of late stillbirth but the performance of prediction is poor.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Arterias Umbilicales / Mortinato Tipo de estudio: Diagnostic_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Female / Humans / Pregnancy País/Región como asunto: Europa Idioma: En Revista: J Matern Fetal Neonatal Med Asunto de la revista: OBSTETRICIA / PERINATOLOGIA Año: 2020 Tipo del documento: Article País de afiliación: España Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Arterias Umbilicales / Mortinato Tipo de estudio: Diagnostic_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Female / Humans / Pregnancy País/Región como asunto: Europa Idioma: En Revista: J Matern Fetal Neonatal Med Asunto de la revista: OBSTETRICIA / PERINATOLOGIA Año: 2020 Tipo del documento: Article País de afiliación: España Pais de publicación: Reino Unido