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Plasma glucose in screening for diabetes and pre-diabetes: how much is too much? Analysis of fasting plasma glucose and oral glucose tolerance test in Sri Lankans.
Katulanda, G W; Katulanda, P; Dematapitiya, C; Dissanayake, H A; Wijeratne, S; Sheriff, M H R; Matthews, D R.
Afiliación
  • Katulanda GW; Medical Research Institute, Colombo, 08, Sri Lanka.
  • Katulanda P; Diabetes Research Unit, Department of Clinical Medicine, Faculty of Medicine, University of Colombo, Colombo, Sri Lanka.
  • Dematapitiya C; Cruddas Link Fellow, Harris Manchester University, University of Oxford, Oxford, UK.
  • Dissanayake HA; Oxford Centre for Diabetes Endocrinology and Metabolism, Oxford, London, UK.
  • Wijeratne S; Diabetes Research Unit, Department of Clinical Medicine, Faculty of Medicine, University of Colombo, Colombo, Sri Lanka.
  • Sheriff MHR; Diabetes Research Unit, Department of Clinical Medicine, Faculty of Medicine, University of Colombo, Colombo, Sri Lanka. dissanayakeha@gmail.com.
  • Matthews DR; Faculty of Medicine, University of Colombo, Colombo, Sri Lanka.
BMC Endocr Disord ; 19(1): 11, 2019 Jan 22.
Article en En | MEDLINE | ID: mdl-30670002
BACKGROUND: Fasting plasma glucose (FPG) is the most commonly used screening tool for diabetes in Sri Lanka. Cut-off values from American Diabetes Association recommendations are adopted in the absence of local data. We aimed to establish FPG cut offs for Sri Lankans to screen for diabetes and pre-diabetes. METHODS: Data on FPG and diabetes/pre-diabetes status were obtained from Sri Lanka Diabetes and Cardiovascular Study (SLDCS), a community based island wide observational study conducted in 2005-6. Sensitivity specificity and area under the ROC curve were calculated for different FPG values. RESULTS: Study included 4014 community dwelling people after excluding people already on treatment for diabetes or pre-diabetes. Mean age was 45.3 (± 15) years and 60.4% were females. FPG cut off of 5.3 mmol/L showed better sensitivity and specificity than 5.6 mmol/L in detecting diabetes (87.8% and 84.4% Vs 80.8% and 92.1%) and pre-diabetes (54.7% and 87.0% Vs 43.8% and 94.2%). CONCLUSIONS: A lower FPG cut off of 5.3 mmol/L has a better sensitivity and acceptable specificity in screening for diabetes and pre-diabetes in Sri Lankan adults.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Estado Prediabético / Glucemia / Biomarcadores / Tamizaje Masivo / Ayuno / Diabetes Mellitus / Prueba de Tolerancia a la Glucosa Tipo de estudio: Diagnostic_studies / Etiology_studies / Guideline / Incidence_studies / Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies / Screening_studies Límite: Female / Humans / Male / Middle aged País/Región como asunto: Asia Idioma: En Revista: BMC Endocr Disord Año: 2019 Tipo del documento: Article País de afiliación: Sri Lanka Pais de publicación: Reino Unido
Texto completo
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XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Estado Prediabético / Glucemia / Biomarcadores / Tamizaje Masivo / Ayuno / Diabetes Mellitus / Prueba de Tolerancia a la Glucosa Tipo de estudio: Diagnostic_studies / Etiology_studies / Guideline / Incidence_studies / Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies / Screening_studies Límite: Female / Humans / Male / Middle aged País/Región como asunto: Asia Idioma: En Revista: BMC Endocr Disord Año: 2019 Tipo del documento: Article País de afiliación: Sri Lanka Pais de publicación: Reino Unido