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Perspectives on the Use of Liquid Extraction for Radioisotope Purification.
Martini, Petra; Adamo, Andrea; Syna, Neilesh; Boschi, Alessandra; Uccelli, Licia; Weeranoppanant, Nopphon; Markham, Jack; Pascali, Giancarlo.
Afiliación
  • Martini P; Department of Morphology, Surgery and Experimental Medicine, University of Ferrara, Via Luigi Borsari, 46-44121 Ferrara, Italy. petra.martini@unife.it.
  • Adamo A; Legnaro National Laboratories, Italian National Institute for Nuclear Physics (LNL-INFN), Viale dell'Università, 2, 35020 Legnaro (PD), Italy. petra.martini@unife.it.
  • Syna N; Zaiput Flow Technologies, 300 2nd Avenue, Waltham, MA 02451, USA. aadamo@zaiput.com.
  • Boschi A; ANSTO Minerals, New Illawarra Rd, Lucas Heights, NSW 2234, Australia. neileshs@ansto.gov.au.
  • Uccelli L; Department of Morphology, Surgery and Experimental Medicine, University of Ferrara, Via Luigi Borsari, 46-44121 Ferrara, Italy. alessandra.boschi@unife.it.
  • Weeranoppanant N; Department of Morphology, Surgery and Experimental Medicine, University of Ferrara, Via Luigi Borsari, 46-44121 Ferrara, Italy. licia.uccelli@unife.it.
  • Markham J; Department of Chemical Engineering, Faculty of Engineering, Burapha University, 169 Longhard Bangsaen, Saensook, Muang, Chonburi 20131, Thailand. nppn2188@gmail.com.
  • Pascali G; ANSTO National Research Cyclotron, 81 Missenden Rd, Camperdown, NSW 2050, Australia. jackm@ansto.gov.au.
Molecules ; 24(2)2019 Jan 18.
Article en En | MEDLINE | ID: mdl-30669256
The reliable and efficient production of radioisotopes for diagnosis and therapy is becoming an increasingly important capability, due to their demonstrated utility in Nuclear Medicine applications. Starting from the first processes involving the separation of 99mTc from irradiated materials, several methods and concepts have been developed to selectively extract the radioisotopes of interest. Even though the initial methods were based on liquid-liquid extraction (LLE) approaches, the perceived difficulty in automating such processes has slowly moved the focus towards resin separation methods, whose basic chemical principles are often similar to the LLE ones in terms of chelators and phases. However, the emerging field of flow chemistry allows LLE to be easily automated and operated in a continuous manner, resulting in an even improved efficiency and reliability. In this contribution, we will outline the fundamentals of LLE processes and their translation into flow-based apparatuses; in addition, we will provide examples of radioisotope separations that have been achieved using LLE methods. This article is intended to offer insights about the future potential of LLE to purify medically relevant radioisotopes.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Radioisótopos / Extracción Líquido-Líquido Idioma: En Revista: Molecules Asunto de la revista: BIOLOGIA Año: 2019 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Suiza
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Radioisótopos / Extracción Líquido-Líquido Idioma: En Revista: Molecules Asunto de la revista: BIOLOGIA Año: 2019 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Suiza