Simultaneous detection of four flavonoids and two alkaloids in rat plasma by LC-MS/MS and its application to a comparative study of the pharmacokinetics between Abri Herba and Abri mollis Herba extract after oral administration.

Liu, Ruina; Yan, Wenying; Han, Qingjie; Lv, Tao; Wang, Xin; Liu, Xiaochen; Fan, Xueyan; Meng, Caifeng; Wang, Chunying

Liu, Ruina; Yan, Wenying; Han, Qingjie; Lv, Tao; Wang, Xin; Liu, Xiaochen; Fan, Xueyan; Meng, Caifeng; Wang, Chunying.

Afiliación

Liu R; Department of Pharmaceutical Analysis, School of Pharmacy, Hebei Medical University, Shijiazhuang, P. R. China.
Yan W; Department of Clinical Pharmacy, The Third Hospital of Hebei Medical University, Shijiazhuang, P. R. China.
Han Q; Department of Pharmaceutical Analysis, School of Pharmacy, Hebei Medical University, Shijiazhuang, P. R. China.
Lv T; Experiment center, School of Pharmacy, Hebei Medical University, Shijiazhuang, P. R. China.
Wang X; Department of Pharmaceutical Analysis, School of Pharmacy, Hebei Medical University, Shijiazhuang, P. R. China.
Liu X; Department of Pharmaceutical Analysis, School of Pharmacy, Hebei Medical University, Shijiazhuang, P. R. China.
Fan X; Department of Pharmaceutical Analysis, School of Pharmacy, Hebei Medical University, Shijiazhuang, P. R. China.
Meng C; Department of Pharmaceutical Analysis, School of Pharmacy, Hebei Medical University, Shijiazhuang, P. R. China.
Wang C; Department of Pharmaceutical Analysis, School of Pharmacy, Hebei Medical University, Shijiazhuang, P. R. China.

J Sep Sci ; 42(7): 1341-1350, 2019 Apr.

Article en En | MEDLINE | ID: mdl-30667179

Asunto(s)

Alcaloides/sangre; Flavonoides/sangre; Extractos Vegetales/farmacocinética; Administración Oral; Animales; Cromatografía Liquida; Medicamentos Herbarios Chinos/química; Masculino; Conformación Molecular; Extractos Vegetales/administración & dosificación; Extractos Vegetales/aislamiento & purificación; Ratas; Ratas Sprague-Dawley; Espectrometría de Masas en Tándem

Palabras clave

high-performance liquid chromatography; pharmacokinetics; tandem mass spectrometry; traditional Chinese medicine

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Flavonoides / Extractos Vegetales / Alcaloides Tipo de estudio: Diagnostic_studies Límite: Animals Idioma: En Revista: J Sep Sci Año: 2019 Tipo del documento: Article Pais de publicación: Alemania

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