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Circular RNA circASS1 is downregulated in breast cancer cells MDA-MB-231 and suppressed invasion and migration.
Hou, Jun-Chen; Xu, Zhi; Zhong, Shan-Liang; Zhang, He-da; Jiang, Lin-Hong; Chen, Xiu; Zhu, Ling-Ping; Li, Jian; Zhou, Si-Ying; Yang, Su-Jin; He, Yun-Jie; Wang, Dan-Dan; Deng, Fei; Zhang, Qian; Wang, Jin-Yan; Hu, Jia-Hua; Zhang, Wei; Wu, Yang; Ding, Li; Zhao, Jian-Hua; Tang, Jin-Hai.
Afiliación
  • Hou JC; Department of General Surgery, the First Affiliated Hospital with Nanjing Medical University, Nanjing 210029, China.
  • Xu Z; Graduate School, The First Clinical School of Nanjing Medical University, Nanjing 210029, China.
  • Zhong SL; Department of General Surgery, the First Affiliated Hospital with Nanjing Medical University, Nanjing 210029, China.
  • Zhang HD; Graduate School, The First Clinical School of Nanjing Medical University, Nanjing 210029, China.
  • Jiang LH; Center of Clinical Laboratory Science, Jiangsu Cancer Hospital & Jiangsu Institute of Cancer Research & Nanjing Medical University Affiliated Cancer Hospital, Nanjing 210009, China.
  • Chen X; Department of General Surgery, Zhong Da Hospital Southeast University, Nanjing 210029, China.
  • Zhu LP; Graduate School, Xuzhou Medical University, Xuzhou 221000, China.
  • Li J; Department of General Surgery, the First Affiliated Hospital with Nanjing Medical University, Nanjing 210029, China.
  • Zhou SY; Department of General Surgery, the First Affiliated Hospital with Nanjing Medical University, Nanjing 210029, China.
  • Yang SJ; Graduate School, The First Clinical School of Nanjing Medical University, Nanjing 210029, China.
  • He YJ; Department of General Surgery, Jiangsu Cancer Hospital & Jiangsu Institute of Cancer Research & Nanjing Medical University Affiliated Cancer Hospital, Nanjing 210009, China.
  • Wang DD; Graduate School, Nanjing University of Chinese Medicine, Xianlin Campus, Nanjing 210029, China.
  • Deng F; Department of General Surgery, the First Affiliated Hospital with Nanjing Medical University, Nanjing 210029, China.
  • Zhang Q; Graduate School, The First Clinical School of Nanjing Medical University, Nanjing 210029, China.
  • Wang JY; Department of General Surgery, the First Affiliated Hospital with Nanjing Medical University, Nanjing 210029, China.
  • Hu JH; Graduate School, The First Clinical School of Nanjing Medical University, Nanjing 210029, China.
  • Zhang W; Department of General Surgery, the First Affiliated Hospital with Nanjing Medical University, Nanjing 210029, China.
  • Wu Y; Department of General Surgery, the First Affiliated Hospital with Nanjing Medical University, Nanjing 210029, China.
  • Ding L; Graduate School, The First Clinical School of Nanjing Medical University, Nanjing 210029, China.
  • Zhao JH; Department of General Surgery, the First Affiliated Hospital with Nanjing Medical University, Nanjing 210029, China.
  • Tang JH; Graduate School, The First Clinical School of Nanjing Medical University, Nanjing 210029, China.
Epigenomics ; 11(2): 199-213, 2019 02.
Article en En | MEDLINE | ID: mdl-30657346
AIM: The study aimed to investigate the role of circular RNA circASS1 in breast cancer cells. MATERIALS & METHODS: Circular RNAs microarray expression profile were analyzed in MCF-7, MDA-MB-231, and qRT-PCR and western blotting were used to quantify expression of circASS1 and its parental gene ASS1. Wound healing, migration and invasion assay were performed. Luciferase assay system was used to detect harbored miRNA. RESULTS: CircASS1 in MDA-MB-231 is downregulated comparing to MCF-7, and overexpression of circASS1 could suppress invasion and migration. While silence, it could promote invasion and migration. MiR-4443 functioning as a tumor promoter gene could be captured by circASS1. ASS1 is upregulated in loss-of-function experiments, while downregulated in gain-of-function experiments. CONCLUSION: CircASS1 suppresses invasion and migration capacity of breast cancer cells and harbored miR-4443.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Mama / MicroARNs / ARN Circular Límite: Female / Humans Idioma: En Revista: Epigenomics Año: 2019 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Mama / MicroARNs / ARN Circular Límite: Female / Humans Idioma: En Revista: Epigenomics Año: 2019 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido