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Interleukin-1 family cytokines and mast cells: activation and inhibition.
Gallenga, C E; Pandolfi, F; Caraffa, Al; Kritas, S K; Ronconi, G; Toniato, E; Martinotti, S; Conti, P.
Afiliación
  • Gallenga CE; Department of Biomedical Sciences and Specialist Surgery, Section of Ophthalmology, University of Ferrara, Italy.
  • Pandolfi F; La Cattolica University, Rome, Italy.
  • Caraffa Al; School of Pharmacy, University of Camerino, Camerino, Italy.
  • Kritas SK; Microbiology and Infectious Diseases, Aristotle University of Thessaloniki, Macedonia, Greece.
  • Ronconi G; UOS Clinica dei Pazienti del Territorio, Policlinico Gemelli, Rome, Italy.
  • Toniato E; Department of Medical, Oral and Biotechnological Sciences, University "G. d'Annunzio" of Chieti-Pescara, Chieti, Italy.
  • Martinotti S; Department of Medical, Oral and Biotechnological Sciences, University "G. d'Annunzio" of Chieti-Pescara, Chieti, Italy.
  • Conti P; Department of Immunology Division, Postgraduate Medical School, University of Chieti-Pescara, Chieti, Italy.
J Biol Regul Homeost Agents ; 33(1): 1-6, 2019.
Article en En | MEDLINE | ID: mdl-30656901
Activated mast cells (MCs) secrete a number of compounds including pro-inflammatory and anti-inflammatory cytokines. MCs are a potential source of cytokines and chemokines which participate in allergic reactions and inflammation. MCs can be activated by IgE through its receptor FceRI, but also by Toll-like receptors and/or interleukin (IL)-1. MCs can be a target for both pro-inflammatory and anti-inflammatory cytokines. IL-1 activates MCs to release inflammatory chemical mediators, and cytokines/chemokines, an effect which can be potentially inhibited by IL-37. In addition, IL-36 is also a powerful cytokine with a pro-inflammatory activity. IL-38 binds IL-36R and inhibits the pro-inflammatory activity of IL-36, thus performing a therapeutic action. In this article we review the role of MCs in relation to pro-inflammatory and anti-inflammatory IL-1 family member cytokines and a possible therapeutic effect in inflammatory disorders.
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Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Citocinas / Interleucina-1 / Mastocitos Límite: Humans Idioma: En Revista: J Biol Regul Homeost Agents Asunto de la revista: BIOLOGIA / BIOQUIMICA Año: 2019 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Italia
Buscar en Google
Añadir a Mi BVS
Imprimir
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PubMed Links

Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Citocinas / Interleucina-1 / Mastocitos Límite: Humans Idioma: En Revista: J Biol Regul Homeost Agents Asunto de la revista: BIOLOGIA / BIOQUIMICA Año: 2019 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Italia