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Genetic influence of cytokine polymorphisms on the clinical outcome of Japanese gastrointestinal cancer patients in palliative care.
Hishida, Asahi; Okugawa, Yoshinaga; Morimoto, Yuhki; Shirai, Yumiko; Okamoto, Kyoko; Momokita, Sachiko; Ogawa, Aki; Tanaka, Koji; Nishikawa, Ryutaro; Toiyama, Yuji; Inoue, Yasuhiro; Sakurai, Hiroyuki; Urata, Hisashi; Tanaka, Motoyoshi; McMillan, Donald C; Miki, Chikao.
Afiliación
  • Hishida A; Department of Preventive Medicine, Nagoya University Graduate School of Medicine, Nagoya, Aichi 466-8550, Japan.
  • Okugawa Y; Department of Surgery, Iga City General Hospital, Iga, Mie 518-0823, Japan.
  • Morimoto Y; Department of Medical Oncology, Iga City General Hospital, Iga, Mie 518-0823, Japan.
  • Shirai Y; Department of Biochemical Laboratory, Iga City General Hospital, Iga, Mie 518-0823, Japan.
  • Okamoto K; Department of Surgery, Iga City General Hospital, Iga, Mie 518-0823, Japan.
  • Momokita S; Department of Nutrition, Iga City General Hospital, Iga, Mie 518-0823, Japan.
  • Ogawa A; Department of Nursing, Iga City General Hospital, Iga, Mie 518-0823, Japan.
  • Tanaka K; Department of Biochemical Laboratory, Iga City General Hospital, Iga, Mie 518-0823, Japan.
  • Nishikawa R; Department of Nursing, Iga City General Hospital, Iga, Mie 518-0823, Japan.
  • Toiyama Y; Department of Surgery, Iga City General Hospital, Iga, Mie 518-0823, Japan.
  • Inoue Y; Department of Gastrointestinal and Pediatric Surgery, Division of Reparative Medicine, Institute of Life Sciences, Mie University Graduate School of Medicine, Tsu, Mie 514-8507, Japan.
  • Sakurai H; Department of Surgery, Iga City General Hospital, Iga, Mie 518-0823, Japan.
  • Urata H; Department of Gastrointestinal and Pediatric Surgery, Division of Reparative Medicine, Institute of Life Sciences, Mie University Graduate School of Medicine, Tsu, Mie 514-8507, Japan.
  • Tanaka M; Department of Gastrointestinal and Pediatric Surgery, Division of Reparative Medicine, Institute of Life Sciences, Mie University Graduate School of Medicine, Tsu, Mie 514-8507, Japan.
  • McMillan DC; Hepatobiliary Pancreatic and Transplant Surgery, Mie University Graduate School of Medicine, Tsu, Mie 514-8507, Japan.
  • Miki C; Department of Surgery, Iga City General Hospital, Iga, Mie 518-0823, Japan.
Oncol Lett ; 17(1): 623-629, 2019 Jan.
Article en En | MEDLINE | ID: mdl-30655809
Gastrointestinal cancer is one of the most common causes of mortality globally. The present study examined the influence of cytokine genetic polymorphisms [interleukin (IL)-1B C-31T, IL-1RN VNTR, IL-6 C-634G, IL-8 T-251A, IL-10 T-819C and IL-10 A-1082G] on clinical outcomes in patients with gastrointestinal cancer in palliative care. A total of 59 patients with gastrointestinal cancer who were admitted to Iga City General Hospital were analyzed. Genotyping was conducted using a polymerase chain reaction with confronting two-pair primers. Patients with at least one IL-1RN 2 allele demonstrated a significantly better survival (P=0.0275) while those with IL-6-634 G/G demonstrated a worse survival (P=0.0024). Multivariate analyses using the Cox proportional hazard model revealed that those with at least one IL-1RN 2 allele, IL-6-634 G/G or IL-10-1082 A/G had a significantly elevated adjusted hazard ratio of 9.20 (P=0.014), 41.01 (P=0.001) or 6.49 (P=0.046), respectively, compared with those with each homozygous wild-type polymorphism. In addition, the evaluation of weight loss by genotype revealed the potential influence of IL-10 T-819C genotype (P=0.072). IL-1RN, IL-6 and IL-10 polymorphisms were associated with the survival of patients with gastrointestinal cancer, suggesting the clinical feasibility of genetic testing in patients with gastrointestinal cancer in palliative care.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Oncol Lett Año: 2019 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Grecia
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Oncol Lett Año: 2019 Tipo del documento: Article País de afiliación: Japón Pais de publicación: Grecia