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Continuous, quantifiable, and simple osmotic preconcentration and sensing within microfluidic devices.
Jajack, Andrew; Stamper, Isaac; Gomez, Eliot; Brothers, Michael; Begtrup, Gavi; Heikenfeld, Jason.
Afiliación
  • Jajack A; Department of Biomedical Engineering, University of Cincinnati, Cincinnati, Ohio, United States of America.
  • Stamper I; Department of Biomedical Engineering, University of Cincinnati, Cincinnati, Ohio, United States of America.
  • Gomez E; Department of Electrical Engineering and Computing Systems, University of Cincinnati, Cincinnati, Ohio, United States of America.
  • Brothers M; Department of Electrical Engineering and Computing Systems, University of Cincinnati, Cincinnati, Ohio, United States of America.
  • Begtrup G; Eccrine Systems, Incorporated, Cincinnati, Ohio, United States of America.
  • Heikenfeld J; Department of Electrical Engineering and Computing Systems, University of Cincinnati, Cincinnati, Ohio, United States of America.
PLoS One ; 14(1): e0210286, 2019.
Article en En | MEDLINE | ID: mdl-30650158
Insurmountable detection challenges will impede the development of many of the next-generation of lab-on-a-chip devices (e.g., point-of-care and real-time health monitors). Here we present the first membrane-based, microfluidic sample preconcentration method that is continuous, quantifiable, simple, and capable of working with any analyte. Forward osmosis rapidly concentrates analytes by removing water from a stream of sample fluid. 10-100X preconcentration is possible in mere minutes. This requires careful selection of the semi-permeable membrane and draw molecule; therefore, the osmosis performance of several classes of membranes and draw molecules were systematically optimized. Proof-of-concept preconcentration devices were characterized based on their concentration ability and fouling resistance. In-silico theoretical modeling predicts the experimental findings and provides an engineering toolkit for future designs. With this toolkit, inexpensive ready-for-manufacturing prototypes were also developed. These devices provide broad-spectrum detection improvements across many analytes and sensing modalities, enabling next-generation lab-on-a-chip devices.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Dispositivos Laboratorio en un Chip Tipo de estudio: Evaluation_studies / Prognostic_studies Límite: Animals / Humans Idioma: En Revista: PLoS One Asunto de la revista: CIENCIA / MEDICINA Año: 2019 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
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XML
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Dispositivos Laboratorio en un Chip Tipo de estudio: Evaluation_studies / Prognostic_studies Límite: Animals / Humans Idioma: En Revista: PLoS One Asunto de la revista: CIENCIA / MEDICINA Año: 2019 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos