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Mitochondrial targeting of TR3 is involved in TPA induced apoptosis in breast cancer cells.
Zhong, Caineng; Mai, Yuchang; Gao, Hengyuan; Zhou, Wenbin; Zhou, Dongxian.
Afiliación
  • Zhong C; Department of Breast Surgery, The Second Affiliated Hospital of Jinan University, Shenzhen People's Hospital, Shenzhen, Guangdong, China. Electronic address: cainengzhong@126.com.
  • Mai Y; Department of Breast Surgery, The Second Affiliated Hospital of Jinan University, Shenzhen People's Hospital, Shenzhen, Guangdong, China.
  • Gao H; Department of Breast Surgery, The Second Affiliated Hospital of Jinan University, Shenzhen People's Hospital, Shenzhen, Guangdong, China.
  • Zhou W; Department of Breast Surgery, The Second Affiliated Hospital of Jinan University, Shenzhen People's Hospital, Shenzhen, Guangdong, China.
  • Zhou D; Department of Breast Surgery, The Second Affiliated Hospital of Jinan University, Shenzhen People's Hospital, Shenzhen, Guangdong, China.
Gene ; 693: 61-68, 2019 Apr 20.
Article en En | MEDLINE | ID: mdl-30641217
TPA is considered to be a tumor promoting molecule that induces the expression of COX-2 protein. However, it is contradictory to find that TPA can induce tumor cell apoptosis and exert antitumor activity. Therefore, the role of TPA in tumorigenesis and development has not yet been elucidated. Here we show that TPA can promote the apoptosis of breast cancer cells and increase the ratio of Bax/Bcl-2. It is suggested that TPA may induce apoptosis of breast cancer cells through mitochondrial apoptosis pathway. Further studies showed that TPA could cause mitochondrial dysfunction and trigger mitochondrial apoptotic pathway. In mechanism, the mitochondrial targeting of TR3 is involved in TPA induced apoptosis in breast cancer cells. In conclusion, our findings suggest that TPA can play a role in inhibiting cancer by inducing apoptosis and TR3 is expected to be a new target for cancer treatment.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Mama / Antígeno Polipéptido de Tejido / Miembro 1 del Grupo A de la Subfamilia 4 de Receptores Nucleares Límite: Female / Humans Idioma: En Revista: Gene Año: 2019 Tipo del documento: Article Pais de publicación: Países Bajos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Mama / Antígeno Polipéptido de Tejido / Miembro 1 del Grupo A de la Subfamilia 4 de Receptores Nucleares Límite: Female / Humans Idioma: En Revista: Gene Año: 2019 Tipo del documento: Article Pais de publicación: Países Bajos