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Genome comparison of African swine fever virus China/2018/AnhuiXCGQ strain and related European p72 Genotype II strains.
Bao, Jingyue; Wang, Qinghua; Lin, Peng; Liu, Chunju; Li, Lin; Wu, Xiaodong; Chi, Tianying; Xu, Tiangang; Ge, Shengqiang; Liu, Yutian; Li, Jinming; Wang, Shujuan; Qu, Hailong; Jin, Tao; Wang, Zhiliang.
Afiliación
  • Bao J; China Animal Health and Epidemiology Center, Qingdao, Shandong, China.
  • Wang Q; China Animal Health and Epidemiology Center, Qingdao, Shandong, China.
  • Lin P; BGI-Qingdao, BGI-Shenzhen, Qingdao, Shandong, China.
  • Liu C; BGI Education Center, University of Chinese Academy of Sciences, Shenzhen, China.
  • Li L; China Animal Health and Epidemiology Center, Qingdao, Shandong, China.
  • Wu X; China Animal Health and Epidemiology Center, Qingdao, Shandong, China.
  • Chi T; China Animal Health and Epidemiology Center, Qingdao, Shandong, China.
  • Xu T; China Animal Health and Epidemiology Center, Qingdao, Shandong, China.
  • Ge S; China Animal Health and Epidemiology Center, Qingdao, Shandong, China.
  • Liu Y; China Animal Health and Epidemiology Center, Qingdao, Shandong, China.
  • Li J; China Animal Health and Epidemiology Center, Qingdao, Shandong, China.
  • Wang S; China Animal Health and Epidemiology Center, Qingdao, Shandong, China.
  • Qu H; China Animal Health and Epidemiology Center, Qingdao, Shandong, China.
  • Jin T; China Animal Health and Epidemiology Center, Qingdao, Shandong, China.
  • Wang Z; BGI-Qingdao, BGI-Shenzhen, Qingdao, Shandong, China.
Transbound Emerg Dis ; 66(3): 1167-1176, 2019 May.
Article en En | MEDLINE | ID: mdl-30637968
African swine fever was introduced into China in August 2018 and led to high mortality in domestic pigs. We reported the genome characterization of the China/2018/AnhuiXCGQ strain mainly based on next-generation sequencing and comparison with related European p72 Genotype II strains. The genome was 189,393 bp long, encoding 181 open reading frames. Pair-wise genome sequence comparison revealed 54-107 variation sites between China/2018/AnhuiXCGQ and the other genotype II virulent strains contributing to the change of expression or alteration of amino acid residues in 10-38 genes. China/2018/AnhuiXCGQ strain shared the highest similarity with POL/2015/Podlaskie strain. Phylogenetic analysis based on a 125 kb long conserved central region revealed that the China/2018/AnhuiXCGQ strain and four European genotype II strains were grouped into three clusters. This study expanded our knowledge on the genetic diversity and evolution of ASFV and provided valuable information for diagnosis improvement and vaccine development.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Variación Genética / Genoma Viral / Genómica / Fiebre Porcina Africana / Virus de la Fiebre Porcina Africana Límite: Animals País/Región como asunto: Asia / Europa Idioma: En Revista: Transbound Emerg Dis Asunto de la revista: MEDICINA VETERINARIA Año: 2019 Tipo del documento: Article País de afiliación: China Pais de publicación: Alemania
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Variación Genética / Genoma Viral / Genómica / Fiebre Porcina Africana / Virus de la Fiebre Porcina Africana Límite: Animals País/Región como asunto: Asia / Europa Idioma: En Revista: Transbound Emerg Dis Asunto de la revista: MEDICINA VETERINARIA Año: 2019 Tipo del documento: Article País de afiliación: China Pais de publicación: Alemania