Exploring the Mechanism of Viral Peptide-Induced Membrane Fusion.
Adv Exp Med Biol
; 1112: 69-78, 2018.
Article
en En
| MEDLINE
| ID: mdl-30637691
Membrane fusion is essential in several cellular processes in the existence of eukaryotic cells such as cellular trafficking, compartmentalization, intercellular communication, sexual reproduction, cell division, and endo- and exocytosis. Membrane fusion proceeds in model membranes as well as biological membranes through the rearrangement of lipids. The stalk hypothesis provides a picture of the general nature of lipid rearrangement based on mechanical properties and phase behavior of water-lipid mesomorphic systems. In spite of extensive research on exploring the mechanism of membrane fusion, a clear molecular understanding of intermediate and pore formation is lacking. In addition, the mechanism by which proteins and peptides reduce the activation energy for stalk and pore formation is not yet clear though there are several propositions on how they catalyze membrane fusion. In this review, we have discussed about various putative functions of fusion peptides by which they reduce activation barrier and thus promote membrane fusion. A careful analysis of the discussed effects of fusion peptides on membranes might open up new possibilities for better understanding of the membrane fusion mechanism.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Membrana Celular
/
Proteínas Virales de Fusión
/
Fusión de Membrana
/
Lípidos de la Membrana
Idioma:
En
Revista:
Adv Exp Med Biol
Año:
2018
Tipo del documento:
Article
País de afiliación:
India
Pais de publicación:
Estados Unidos