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Septic shock due to Candida famata (Debaryomyces hansenii) candidemia in an ICU immunocompetent trauma-patient.
Karapetsa, Maria; Tsolaki, Vasiliki; Arabatzis, Michael; Petinaki, Efi; Velegraki, Aristea; Zakynthinos, Epaminondas.
Afiliación
  • Karapetsa M; Department of Intensive Care, University Hospital of Thessaly Biopolis, Larissa, Greece.
  • Tsolaki V; Department of Intensive Care, University Hospital of Thessaly Biopolis, Larissa, Greece. Electronic address: vasotsolaki@yahoo.com.
  • Arabatzis M; Mycology Research Laboratory, Department of Microbiology, Medical School, National and Kapodistrian University of Athens, Athens, Greece; First Department of Dermatology-Venereology, Medical School, Aristotle University, Thessaloniki, Greece.
  • Petinaki E; Department of Microbiology, University of Thessaly, Larissa, Greece.
  • Velegraki A; Mycology Research Laboratory, Department of Microbiology, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
  • Zakynthinos E; Department of Intensive Care, University Hospital of Thessaly Biopolis, Larissa, Greece.
J Infect Public Health ; 12(4): 594-597, 2019.
Article en En | MEDLINE | ID: mdl-30635251
Sepsis related to Candida famata (C. famata) fungemia is extremely rare in immunocompetent patients. Moreover, septic shock has not been reported due to this yeast. A previously healthy young multi-trauma male, presented septic shock from C. famata, after he had been admitted in the Intensive Care Unit (ICU) due to haemorrhagic shock. Risk factors for candidemia in ICU patients are the presence of a central venous catheter (CVC), Total Parenteral Nutrition (TPN), use of broad-spectrum antimicrobials, immunosuppression and the length of ICU stay. The presence of CVCs, prior use of antibiotics, prolonged hospitalization, disruption of skin flora and immunocompromised states have been identified as predisposing risk factors for C. famata fungemia. It is worth noting that the present case concerns a non-immunocompromised patient, but long ICU stay and brain injury may indicate a state of immunoparalysis. Identification of the yeast was performed by partial amplification and sequencing of the 26S ribosomal DNA gene [hypervariable region D1/D2; partial sequencing of the act1 gene confirmed the identity of the strain as Debaryomyces hansenii (GenBank submission ID: 1688297)] The patient quickly recovered from sepsis after initiation of amphotericin B and was discharged on the 60th day.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Choque Séptico / Heridas y Lesiones / Candidemia / Inmunocompetencia / Unidades de Cuidados Intensivos Tipo de estudio: Etiology_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Humans / Male Idioma: En Revista: J Infect Public Health Asunto de la revista: DOENCAS TRANSMISSIVEIS / SAUDE PUBLICA Año: 2019 Tipo del documento: Article País de afiliación: Grecia Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Choque Séptico / Heridas y Lesiones / Candidemia / Inmunocompetencia / Unidades de Cuidados Intensivos Tipo de estudio: Etiology_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Humans / Male Idioma: En Revista: J Infect Public Health Asunto de la revista: DOENCAS TRANSMISSIVEIS / SAUDE PUBLICA Año: 2019 Tipo del documento: Article País de afiliación: Grecia Pais de publicación: Reino Unido