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HDL3-C is a Marker of Coronary Artery Disease Severity and Inflammation in Patients on Statin Therapy.
Chaudhary, Rahul; Kinderyte, Marija; Chaudhary, Rohit; Sukhi, Ajaypaul; Bliden, Kevin; Tantry, Udaya; Gurbel, Paul.
Afiliación
  • Chaudhary R; Sinai Hospital of Baltimore, Baltimore, MD, USA.
  • Kinderyte M; Inova Center for Thrombosis Research and Drug Development, Inova Heart and Vascular Institute, Falls Church FVA, USA.
  • Chaudhary R; Peter Lee Associates, Sydney, Australia.
  • Sukhi A; Sinai Hospital of Baltimore, Baltimore, MD, USA.
  • Bliden K; Inova Center for Thrombosis Research and Drug Development, Inova Heart and Vascular Institute, Falls Church FVA, USA.
  • Tantry U; Platelet and Thrombosis Research, Baltimore, MD, USA.
  • Gurbel P; Inova Center for Thrombosis Research and Drug Development, Inova Heart and Vascular Institute, Falls Church FVA, USA. Electronic address: Paul.Gurbel@inova.org.
Cardiovasc Revasc Med ; 20(11): 1001-1006, 2019 11.
Article en En | MEDLINE | ID: mdl-30626544
INTRODUCTION: Low high-density lipoprotein (HDL-C) and inflammation are risk factors for coronary artery disease (CAD). However, limited data are available determining the role of HDL-C sub-particles HDL2-C and HDL3-C for assessing CAD severity in patients on statin therapy. METHODS: Blood samples were obtained prior to cardiac catheterization in 304 consecutive patients with suspected CAD on statin therapy in this sub-analysis of Multi-Analyte, thrombogenic, and Genetic Markers of Atherosclerosis (MAGMA, NCT01276678) study. Detailed lipid profiling and oxidized LDL (ox-LDL) were analyzed. CAD severity was angiographically defined as severe CAD (>75% luminal diameter stenosis [LDS]) and non-severe CAD (≤75% LDS). Multi-regression analysis was performed to test for statistical significance. Receiver operator curve (ROC) analysis was performed to determine cut-point for predicting severe CAD. RESULTS: Patients with severe CAD had a significantly lower total-HDL-C, lower HDL3-C and higher lipoprotein(a) levels. HDL3-C and lipoprotein(a) cholesterol [Lp(a)-C] retained statistical significance on multiple regression analysis. ROC analysis showed HDL3-C to have a C-statistic of 0.60 (p = 0.003) and Lp(a)-C to have a C-statistic of 0.61 (p = 0.0007). Patients with HDL3-C ≤ 33 mg/dL and Lp(a)-C > 7 mg/dL were found to have significantly elevated ox-LDL levels. CONCLUSION: In patients on statin therapy, HDL3-C and Lp(a)-C improve prediction of severe CAD compared to a traditional lipid panel. In addition, patients with HDL3-C ≤ 33 mg/dL and Lp(a)-C > 7 mg/dL have greater inflammation marked by ox-LDL. Further studies are needed to evaluate the utility of these novel biomarkers in predicting CAD severity.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedad de la Arteria Coronaria / Inhibidores de Hidroximetilglutaril-CoA Reductasas / Dislipidemias / Lipoproteínas HDL3 / Inflamación / HDL-Colesterol Tipo de estudio: Diagnostic_studies / Etiology_studies / Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Cardiovasc Revasc Med Asunto de la revista: ANGIOLOGIA / CARDIOLOGIA Año: 2019 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedad de la Arteria Coronaria / Inhibidores de Hidroximetilglutaril-CoA Reductasas / Dislipidemias / Lipoproteínas HDL3 / Inflamación / HDL-Colesterol Tipo de estudio: Diagnostic_studies / Etiology_studies / Observational_studies / Prevalence_studies / Prognostic_studies / Risk_factors_studies Límite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Cardiovasc Revasc Med Asunto de la revista: ANGIOLOGIA / CARDIOLOGIA Año: 2019 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos