The GLP-1 Analogs Liraglutide and Semaglutide Reduce Atherosclerosis in ApoE<sup>-/-</sup> and LDLr<sup>-/-</sup> Mice by a Mechanism That Includes Inflammatory Pathways.

Rakipovski, Günaj; Rolin, Bidda; Nøhr, Jane; Klewe, Ib; Frederiksen, Klaus S; Augustin, Robert; Hecksher-Sørensen, Jacob; Ingvorsen, Camilla; Polex-Wolf, Joseph; Knudsen, Lotte Bjerre

The GLP-1 Analogs Liraglutide and Semaglutide Reduce Atherosclerosis in ApoE^-/- and LDLr^-/- Mice by a Mechanism That Includes Inflammatory Pathways.

Rakipovski, Günaj; Rolin, Bidda; Nøhr, Jane; Klewe, Ib; Frederiksen, Klaus S; Augustin, Robert; Hecksher-Sørensen, Jacob; Ingvorsen, Camilla; Polex-Wolf, Joseph; Knudsen, Lotte Bjerre.

Afiliación

Rakipovski G; Global Research, Novo Nordisk A/S, Maaloev, Denmark.
Rolin B; Global Research, Novo Nordisk A/S, Maaloev, Denmark.
Nøhr J; Global Research, Novo Nordisk A/S, Maaloev, Denmark.
Klewe I; Biopeople, University of Copenhagen, Copenhagen, Denmark.
Frederiksen KS; Global Research, Novo Nordisk A/S, Maaloev, Denmark.
Augustin R; Department of Signal Transduction, Lundbeck, Copenhagen, Denmark.
Hecksher-Sørensen J; Global Research, Novo Nordisk A/S, Maaloev, Denmark.
Ingvorsen C; Global Research, Novo Nordisk A/S, Maaloev, Denmark.
Polex-Wolf J; Global Research, Novo Nordisk A/S, Maaloev, Denmark.
Knudsen LB; Gubra, Hørsholm, Denmark.

JACC Basic Transl Sci ; 3(6): 844-857, 2018 Dec.

Article en En | MEDLINE | ID: mdl-30623143

Palabras clave

CD163, cluster of differentiation 163 molecule; GLP, glucagon-like peptide; GLP-1; IFN, interferon; IL, interleukin; LDL, low-density lipoprotein; LPS, lipopolysaccharide; MMP, matrix metalloproteinase; NASH, nonalcoholic steatohepatitis; OPN, osteopontin; RNA, ribonucleic acid; TIMP, tissue inhibitor of metalloproteinases; TNF, tumor necrosis factor; WD, Western diet; atherosclerosis; diabetes; inflammation; obesity

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: JACC Basic Transl Sci Año: 2018 Tipo del documento: Article País de afiliación: Dinamarca Pais de publicación: Estados Unidos

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