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A Possible Reason to Induce Acute Graft-vs.-Host Disease After Hematopoietic Stem Cell Transplantation: Lack of Sirtuin-1 in CD4+ T Cells.
Xu, Ya-Jing; Chen, Fang-Ping; Chen, Yan; Fu, Bin; Liu, En-Yi; Zou, Lang; Liu, Lin-Xin.
Afiliación
  • Xu YJ; Department of Hematology, Xiangya Hospital, Central South University, Changsha, China.
  • Chen FP; Department of Hematology, Xiangya Hospital, Central South University, Changsha, China.
  • Chen Y; Department of Hematology, Xiangya Hospital, Central South University, Changsha, China.
  • Fu B; Department of Hematology, Xiangya Hospital, Central South University, Changsha, China.
  • Liu EY; Department of Hematology, Xiangya Hospital, Central South University, Changsha, China.
  • Zou L; Department of Hematology, Xiangya Hospital, Central South University, Changsha, China.
  • Liu LX; Department of Hematology, Xiangya Hospital, Central South University, Changsha, China.
Front Immunol ; 9: 3078, 2018.
Article en En | MEDLINE | ID: mdl-30622543
Sirtuin 1 (SIRT1) is a critical suppressor of T cell immunity. However, whether SIRT1 is involved in the progression of acute graft-vs.-host disease (aGVHD) has still remained unclear. PI3K/Akt/mTOR pathway is a crucial element involved in the activation and functions of T cells. Over-activation of PI3K/Akt/mTOR signaling may be related to the occurrence of aGVHD. STAT3 activation requires phosphorylation and acetylation. A recent study showed that STAT3 hyperphosphorylation in CD4+ T cells may be a trigger of aGVHD. The role of the STAT3 acetylation in aGVHD pathogenesis is still unclear. The present study revealed that SIRT1 deficiency as a critical factor is involved in the excessive activation of mTOR pathway and upregulation of STAT3 acetylation and phosphorylation in CD4+ T cells from patients with aGVHD. Exorbitant activation of IL-1ß signaling is the main reason for TAK1-dependent SIRT1 insufficiency. The findings of the present study might provide a new therapeutic target for treating aGVHD.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Linfocitos T CD4-Positivos / Trasplante de Células Madre Hematopoyéticas / Neoplasias Hematológicas / Sirtuina 1 / Enfermedad Injerto contra Huésped Límite: Adult / Female / Humans / Male Idioma: En Revista: Front Immunol Año: 2018 Tipo del documento: Article País de afiliación: China Pais de publicación: Suiza
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Linfocitos T CD4-Positivos / Trasplante de Células Madre Hematopoyéticas / Neoplasias Hematológicas / Sirtuina 1 / Enfermedad Injerto contra Huésped Límite: Adult / Female / Humans / Male Idioma: En Revista: Front Immunol Año: 2018 Tipo del documento: Article País de afiliación: China Pais de publicación: Suiza