Proteasome Inhibition in Multiple Myeloma: Head-to-Head Comparison of Currently Available Proteasome Inhibitors.

Besse, Andrej; Besse, Lenka; Kraus, Marianne; Mendez-Lopez, Max; Bader, Jürgen; Xin, Bo-Tao; de Bruin, Gerjan; Maurits, Elmer; Overkleeft, Herman S; Driessen, Christoph

Besse, Andrej; Besse, Lenka; Kraus, Marianne; Mendez-Lopez, Max; Bader, Jürgen; Xin, Bo-Tao; de Bruin, Gerjan; Maurits, Elmer; Overkleeft, Herman S; Driessen, Christoph.

Afiliación

Besse A; Experimental Oncology and Hematology, Department of Oncology and Hematology, Cantonal Hospital St. gallen, Rorschacher Strasse 95, St. Gallen 9007, Switzerland.
Besse L; Experimental Oncology and Hematology, Department of Oncology and Hematology, Cantonal Hospital St. gallen, Rorschacher Strasse 95, St. Gallen 9007, Switzerland. Electronic address: lenka.besse@kssg.ch.
Kraus M; Experimental Oncology and Hematology, Department of Oncology and Hematology, Cantonal Hospital St. gallen, Rorschacher Strasse 95, St. Gallen 9007, Switzerland.
Mendez-Lopez M; Experimental Oncology and Hematology, Department of Oncology and Hematology, Cantonal Hospital St. gallen, Rorschacher Strasse 95, St. Gallen 9007, Switzerland.
Bader J; Experimental Oncology and Hematology, Department of Oncology and Hematology, Cantonal Hospital St. gallen, Rorschacher Strasse 95, St. Gallen 9007, Switzerland.
Xin BT; Gorlaeus Laboratories, Leiden Institute of Chemistry and Netherlands Proteomics Centre, 2333 CC Leiden, the Netherlands.
de Bruin G; Gorlaeus Laboratories, Leiden Institute of Chemistry and Netherlands Proteomics Centre, 2333 CC Leiden, the Netherlands.
Maurits E; Gorlaeus Laboratories, Leiden Institute of Chemistry and Netherlands Proteomics Centre, 2333 CC Leiden, the Netherlands.
Overkleeft HS; Gorlaeus Laboratories, Leiden Institute of Chemistry and Netherlands Proteomics Centre, 2333 CC Leiden, the Netherlands.
Driessen C; Experimental Oncology and Hematology, Department of Oncology and Hematology, Cantonal Hospital St. gallen, Rorschacher Strasse 95, St. Gallen 9007, Switzerland.

Cell Chem Biol ; 26(3): 340-351.e3, 2019 03 21.

Article en En | MEDLINE | ID: mdl-30612952

Asunto(s)

Antineoplásicos/metabolismo; Complejo de la Endopetidasa Proteasomal/metabolismo; Inhibidores de Proteasoma/metabolismo; Anciano; Animales; Antineoplásicos/química; Antineoplásicos/farmacología; Antineoplásicos/uso terapéutico; Apoptosis/efectos de los fármacos; Bortezomib/metabolismo; Bortezomib/farmacología; Bortezomib/uso terapéutico; Resistencia a Antineoplásicos/efectos de los fármacos; Femenino; Humanos; Masculino; Ratones; Ratones Endogámicos BALB C; Persona de Mediana Edad; Mieloma Múltiple/tratamiento farmacológico; Mieloma Múltiple/metabolismo; Mieloma Múltiple/patología; Oligopéptidos/metabolismo; Oligopéptidos/farmacología; Oligopéptidos/uso terapéutico; Complejo de la Endopetidasa Proteasomal/química; Inhibidores de Proteasoma/farmacología; Inhibidores de Proteasoma/uso terapéutico; Subunidades de Proteína/antagonistas & inhibidores; Subunidades de Proteína/metabolismo; Distribución Tisular; Células Tumorales Cultivadas

Palabras clave

activity-based probes; bortezomib; carfilzomib; multiple myeloma; proteasome; proteasome inhibitors; resistance

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Complejo de la Endopetidasa Proteasomal / Inhibidores de Proteasoma / Antineoplásicos Límite: Aged / Animals / Female / Humans / Male / Middle aged Idioma: En Revista: Cell Chem Biol Año: 2019 Tipo del documento: Article País de afiliación: Suiza Pais de publicación: Estados Unidos

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