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Sclareol-loaded lipid nanoparticles improved metabolic profile in obese mice.
Cerri, Gabriela Cavazza; Lima, Leandro Ceotto Freitas; Lelis, Deborah de Farias; Barcelos, Lucíola da Silva; Feltenberger, John David; Mussi, Samuel Vidal; Monteiro-Junior, Renato Sobral; Santos, Robson Augusto Souza Dos; Ferreira, Lucas Antônio Miranda; Santos, Sérgio Henrique Sousa.
Afiliación
  • Cerri GC; Department of Physiology and Pharmacology, Institute of Biological Sciences, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
  • Lima LCF; Department of Physiology and Pharmacology, Institute of Biological Sciences, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
  • Lelis DF; Laboratory of Health Science, Postgraduate Program in Health Sciences, Universidade Estadual de Montes Claros, Montes Claros, Minas Gerais, Brazil.
  • Barcelos LDS; Department of Physiology and Pharmacology, Institute of Biological Sciences, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
  • Feltenberger JD; Health Sciences Center, School of Medicine, Texas Tech University, Lubbock, TX, United States.
  • Mussi SV; Department of Pharmaceutics, Faculty of Pharmacy, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
  • Monteiro-Junior RS; Laboratory of Health Science, Postgraduate Program in Health Sciences, Universidade Estadual de Montes Claros, Montes Claros, Minas Gerais, Brazil.
  • Santos RASD; Department of Physiology and Pharmacology, Institute of Biological Sciences, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
  • Ferreira LAM; Department of Pharmaceutics, Faculty of Pharmacy, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
  • Santos SHS; Laboratory of Health Science, Postgraduate Program in Health Sciences, Universidade Estadual de Montes Claros, Montes Claros, Minas Gerais, Brazil; Institute of Agricultural Sciences, Food Engineering College, Universidade Federal de Minas Gerais, Montes Claros, Minas Gerais, Brazil. Electronic addr
Life Sci ; 218: 292-299, 2019 Feb 01.
Article en En | MEDLINE | ID: mdl-30610871
Sclareol is a bioactive hydrophobic diterpene in the essential oil isolated from Salvia sclarea (Fam. Lamiaceae). Sclareol has been widely studied due to its anti-inflammatory and antioxidant effects. AIMS: The present study aimed to evaluate the effects of Sclareol in different formulations (solid lipid nanoparticle and free) on the metabolic profile of obese mice. MAIN METHODS: Swiss male mice were randomly divided into two groups: standard diet (STD) and high-fat diet (HFD). After obesity induction, each group was divided into three treatment groups: free Sclareol (Sc), Sclareol-loaded lipid nanoparticle (L-Sc) and blank lipid nanoparticle (L). Treatments were performed every day during 30 days. KEY FINDINGS: L-Sc improves obese mice metabolic profile by decreasing adiposity, ameliorating insulin sensitivity, glucose tolerance and increasing the HDL plasma levels. In addition, L-Sc decreased the expression of NF-KB, MCP-1 and SERBP-1. SIGNIFICANCE: The use of sclareol together with lipid nanocarriers may be promising for the treatment of metabolic disorders by reducing adipose tissue.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Intolerancia a la Glucosa / Diterpenos / Nanopartículas / Metaboloma / Lípidos / Obesidad Tipo de estudio: Etiology_studies Límite: Animals Idioma: En Revista: Life Sci Año: 2019 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Países Bajos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Intolerancia a la Glucosa / Diterpenos / Nanopartículas / Metaboloma / Lípidos / Obesidad Tipo de estudio: Etiology_studies Límite: Animals Idioma: En Revista: Life Sci Año: 2019 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Países Bajos