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Characterization and Hypoglycemic Activity of a Rhamnan-Type Sulfated Polysaccharide Derivative.
Cui, Jie-Fen; Ye, Han; Zhu, Yu-Jie; Li, Yin-Ping; Wang, Jing-Feng; Wang, Peng.
Afiliación
  • Cui JF; College of Food Science and Engineering, Ocean University of China, Qingdao 266003, China. cjfouc@163.com.
  • Ye H; College of Food Science and Engineering, Ocean University of China, Qingdao 266003, China. 17852720293@163.com.
  • Zhu YJ; College of Food Science and Engineering, Ocean University of China, Qingdao 266003, China. zyjbmgf@163.com.
  • Li YP; College of Food Science and Engineering, Ocean University of China, Qingdao 266003, China. fmsboc@163.com.
  • Wang JF; College of Marine Science and Biological Engineering, Qingdao University of Science and Technology, Qingdao 266042, China. fmsboc@163.com.
  • Wang P; College of Food Science and Engineering, Ocean University of China, Qingdao 266003, China. jfwang@ouc.edu.cn.
Mar Drugs ; 17(1)2019 Jan 01.
Article en En | MEDLINE | ID: mdl-30609655
Polysaccharide chromium (III) derivatives are gaining increasing attention in improving type 2 diabetes. In this study, the sulfated polysaccharide from Enteromorpha prolifera (SPE) with 4.8 kDa was prepared by specific enzymatic hydrolysis. The obtained SPE was used to prepare a rhamnan-type sulfated polysaccharide derivative (SPED). Results indicated that O-H, C=O, and S=O were effectively involved in the chelation of SPED (chromium content 20.26%). Acute (half lethal dose > 2.38 g/kg) and sub-acute toxicity showed that SPED had no damaging effects on mice. Anti-diabetic experiment demonstrated that SPED improved glucose metabolism. Moreover, SPED promoted the PI3K/PKB/GSK-3ß signaling pathway by regulating mRNA expression of insulin receptors (IR), insulin receptor substrate 2 (IRS-2), phosphatidylinositol 3 kinase (PI3K), protein kinase B (PKB), and glycogen synthase kinase 3ß (GSK-3ß). In conclusion, the SPED might represent a novel marine-derived candidate against hyperglycemia, which may undergo further pharmaceutical development as a hypoglycemic agent.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Polisacáridos / Desoxiazúcares / Transducción de Señal / Hiperglucemia / Hipoglucemiantes / Mananos Límite: Animals Idioma: En Revista: Mar Drugs Asunto de la revista: BIOLOGIA / FARMACOLOGIA Año: 2019 Tipo del documento: Article País de afiliación: China Pais de publicación: Suiza
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Polisacáridos / Desoxiazúcares / Transducción de Señal / Hiperglucemia / Hipoglucemiantes / Mananos Límite: Animals Idioma: En Revista: Mar Drugs Asunto de la revista: BIOLOGIA / FARMACOLOGIA Año: 2019 Tipo del documento: Article País de afiliación: China Pais de publicación: Suiza