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Evaluation of in vitro cytotoxicity of superparamagnetic poly(thioether-ester) nanoparticles on erythrocytes, non-tumor (NIH3T3), tumor (HeLa) cells and hyperthermia studies.
Mattos Dos Santos, Paula Christina; Feuser, Paulo Emilio; Cardoso, Priscilla Barreto; Steiner, Bethina Trevisol; Córneo, Emily da Silva; Scussel, Rahisa; Viegas, Alexandre da Cas; Machado-de-Ávila, Ricardo Andrez; Sayer, Claudia; Hermes de Araújo, Pedro Henrique.
Afiliación
  • Mattos Dos Santos PC; a Department of Chemical Engineering and Food Engineering , Federal University of Santa Catarina , Florianópolis , Brazil.
  • Feuser PE; a Department of Chemical Engineering and Food Engineering , Federal University of Santa Catarina , Florianópolis , Brazil.
  • Cardoso PB; a Department of Chemical Engineering and Food Engineering , Federal University of Santa Catarina , Florianópolis , Brazil.
  • Steiner BT; b Postgraduate Program in Health Science , University of Southern Santa Catarina , Florianópolis , Brazil.
  • Córneo EDS; b Postgraduate Program in Health Science , University of Southern Santa Catarina , Florianópolis , Brazil.
  • Scussel R; b Postgraduate Program in Health Science , University of Southern Santa Catarina , Florianópolis , Brazil.
  • Viegas ADC; c Institute of Physics , Federal University of Rio Grande do Sul , Porto Alegre , RS , Brazil.
  • Machado-de-Ávila RA; b Postgraduate Program in Health Science , University of Southern Santa Catarina , Florianópolis , Brazil.
  • Sayer C; a Department of Chemical Engineering and Food Engineering , Federal University of Santa Catarina , Florianópolis , Brazil.
  • Hermes de Araújo PH; a Department of Chemical Engineering and Food Engineering , Federal University of Santa Catarina , Florianópolis , Brazil.
J Biomater Sci Polym Ed ; 29(16): 1935-1948, 2018 11.
Article en En | MEDLINE | ID: mdl-30609380
Magnetic nanoparticles encapsulated in biocompatible and biodegradable polymeric matrices are promising materials for biomedical applications, such as transport of antitumoral drugs and cancer treatment by hyperthermia. In this study, biobased poly(thioether-ester), PTEe, was obtained by thiol-ene polymerization and superparamagnetic nanoparticles, MNPs, were successfully incorporated in PTEe nanoparticles by miniemulsification followed by solvent evaporation. MNPs-PTEe nanoparticles with average diameter around 150 nm presented superparamagnetic behavior as confirmed by magnetization curves analysis. MNPs-PTEe nanoparticles did not present hemolytic damage on human red blood cells when incubated for 24 h. According to the cell viability assays, nanoparticles did not present any cytotoxic effect on murine fibroblast cell (NIH3T3) and human cervical cancer (HeLa). Hyperthermia assays were applied, demonstrating that AC magnetic field application (110 KHz-500 Oe) for 20 min significantly reduced the cells viability. The morphology evaluation of HeLa showed a hypoxia region one hour after hyperthermia application. Therefore, the results indicated that the superparamagnetic poly(thioether-ester) nanoparticles can be an excellent alternative for the targeted delivery of antitumor drugs and cancer treatment for hyperthermia.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Poliésteres / Sulfuros / Eritrocitos / Nanopartículas de Magnetita Límite: Animals / Humans Idioma: En Revista: J Biomater Sci Polym Ed Asunto de la revista: ENGENHARIA BIOMEDICA Año: 2018 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Poliésteres / Sulfuros / Eritrocitos / Nanopartículas de Magnetita Límite: Animals / Humans Idioma: En Revista: J Biomater Sci Polym Ed Asunto de la revista: ENGENHARIA BIOMEDICA Año: 2018 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Reino Unido