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Histamine and diabetic nephropathy: an up-to-date overview.
Pini, Alessandro; Verta, Roberta; Grange, Cristina; Gurrieri, Maura; Rosa, Arianna Carolina.
Afiliación
  • Pini A; Department of Experimental and Clinical Medicine,University of Florence, Viale Pieraccini 6, Florence 50139, Italy.
  • Verta R; Dipartimento di Scienza e Tecnologia del Farmaco, University of Turin, Via P. Giuria 9, Turin 10125, Italy.
  • Grange C; Dipartimento di Scienze Mediche, University of Turin, C.So Dogliotti 14, Turin 10126, Italy.
  • Gurrieri M; Dipartimento di Scienze Mediche, University of Turin, C.So Dogliotti 14, Turin 10126, Italy.
  • Rosa AC; Dipartimento di Scienza e Tecnologia del Farmaco, University of Turin, Via P. Giuria 9, Turin 10125, Italy.
Clin Sci (Lond) ; 133(1): 41-54, 2019 01 15.
Article en En | MEDLINE | ID: mdl-30606813
The classification of diabetic nephropathy (DN) as a vascular complication of diabetes makes the possible involvement of histamine, an endogenous amine that is well known for its vasoactive properties, an interesting topic for study. The aim of the present review is to provide an extensive overview of the possible involvement of histamine in the onset and progression of DN. The evidence collected on the role of histamine in kidney function together with its well-known pleiotropic action suggest that this amine may act simultaneously on glomerular hyperfiltration, tubular inflammation, fibrosis development and tubular hypertrophy.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Vasos Sanguíneos / Histamina / Angiopatías Diabéticas / Nefropatías Diabéticas / Tasa de Filtración Glomerular / Hemodinámica / Riñón Límite: Animals / Humans Idioma: En Revista: Clin Sci (Lond) Año: 2019 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Vasos Sanguíneos / Histamina / Angiopatías Diabéticas / Nefropatías Diabéticas / Tasa de Filtración Glomerular / Hemodinámica / Riñón Límite: Animals / Humans Idioma: En Revista: Clin Sci (Lond) Año: 2019 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Reino Unido