Biphenyl-3-oxo-1,2,4-triazine linked piperazine derivatives as potential cholinesterase inhibitors with anti-oxidant property to improve the learning and memory.

Tripathi, Prabhash Nath; Srivastava, Pavan; Sharma, Piyoosh; Tripathi, Manish Kumar; Seth, Ankit; Tripathi, Avanish; Rai, Sachchida Nand; Singh, Surya Pratap; Shrivastava, Sushant K

Tripathi, Prabhash Nath; Srivastava, Pavan; Sharma, Piyoosh; Tripathi, Manish Kumar; Seth, Ankit; Tripathi, Avanish; Rai, Sachchida Nand; Singh, Surya Pratap; Shrivastava, Sushant K.

Afiliación

Tripathi PN; Pharmaceutical Chemistry Research Laboratory, Department of Pharmaceutical Engineering & Technology, Indian Institute of Technology (Banaras Hindu University), Varanasi 221 005 India.
Srivastava P; Pharmaceutical Chemistry Research Laboratory, Department of Pharmaceutical Engineering & Technology, Indian Institute of Technology (Banaras Hindu University), Varanasi 221 005 India.
Sharma P; Pharmaceutical Chemistry Research Laboratory, Department of Pharmaceutical Engineering & Technology, Indian Institute of Technology (Banaras Hindu University), Varanasi 221 005 India.
Tripathi MK; Pharmaceutical Chemistry Research Laboratory, Department of Pharmaceutical Engineering & Technology, Indian Institute of Technology (Banaras Hindu University), Varanasi 221 005 India.
Seth A; Pharmaceutical Chemistry Research Laboratory, Department of Pharmaceutical Engineering & Technology, Indian Institute of Technology (Banaras Hindu University), Varanasi 221 005 India.
Tripathi A; Pharmaceutical Chemistry Research Laboratory, Department of Pharmaceutical Engineering & Technology, Indian Institute of Technology (Banaras Hindu University), Varanasi 221 005 India.
Rai SN; Department of Biochemistry, Institute of Science, Banaras Hindu University, Varanasi 221005, India.
Singh SP; Department of Biochemistry, Institute of Science, Banaras Hindu University, Varanasi 221005, India.
Shrivastava SK; Pharmaceutical Chemistry Research Laboratory, Department of Pharmaceutical Engineering & Technology, Indian Institute of Technology (Banaras Hindu University), Varanasi 221 005 India. Electronic address: skshrivastava.phe@itbhu.ac.in.

Bioorg Chem ; 85: 82-96, 2019 04.

Article en En | MEDLINE | ID: mdl-30605887

Asunto(s)

Inhibidores de la Colinesterasa/farmacología; Aprendizaje/efectos de los fármacos; Memoria/efectos de los fármacos; Nootrópicos/farmacología; Piperazinas/farmacología; Triazinas/farmacología; Acetilcolinesterasa/química; Acetilcolinesterasa/metabolismo; Animales; Antioxidantes/síntesis química; Antioxidantes/metabolismo; Antioxidantes/farmacología; Compuestos de Bifenilo/síntesis química; Compuestos de Bifenilo/metabolismo; Compuestos de Bifenilo/farmacología; Dominio Catalítico; Línea Celular Tumoral; Inhibidores de la Colinesterasa/síntesis química; Inhibidores de la Colinesterasa/metabolismo; Diseño de Fármacos; Humanos; Masculino; Ratones; Simulación del Acoplamiento Molecular; Simulación de Dinámica Molecular; Nootrópicos/síntesis química; Nootrópicos/metabolismo; Piperazinas/síntesis química; Piperazinas/metabolismo; Unión Proteica; Torpedo; Triazinas/síntesis química; Triazinas/metabolismo

Palabras clave

1,2,4-triazine; Acetylcholinesterase; Alzheimer's disease; Butyrylcholinesterase; Cognitive dysfunctions; Donepezil; PAMPA-BBB; Piperazine

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Piperazinas / Triazinas / Inhibidores de la Colinesterasa / Nootrópicos / Aprendizaje / Memoria Límite: Animals / Humans / Male Idioma: En Revista: Bioorg Chem Año: 2019 Tipo del documento: Article Pais de publicación: Estados Unidos

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