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Evolutionary dynamics in pre-invasive neoplasia.
Abbosh, Christopher; Venkatesan, Subramanian; Janes, Samuel M; Fitzgerald, Rebecca C; Swanton, Charles.
Afiliación
  • Abbosh C; UCL Cancer Institute, CRUK Lung Cancer Centre of Excellence, Paul O'Gorman Building, Huntley St., London WC1E 6DD, UK.
  • Venkatesan S; UCL Cancer Institute, CRUK Lung Cancer Centre of Excellence, Paul O'Gorman Building, Huntley St., London WC1E 6DD, UK.
  • Janes SM; Translational Cancer Therapeutics Lab, The Francis Crick Institute, 1 Midland Road, London, NW1 1AT.
  • Fitzgerald RC; Lungs for Living Research Centre, UCL Respiratory, Division of Medicine, Rayne Building, University College London, London, UK.
  • Swanton C; MRC Cancer Unit, University of Cambridge, Hutchison/MRC Research Centre, Cambridge, United Kingdom.
Curr Opin Syst Biol ; 2: 1-8, 2017 Apr.
Article en En | MEDLINE | ID: mdl-30603736
Mutational processes occur in normal tissues from conception throughout life. Field cancerization describes the preconditioning of an area of epithelium to tumor growth. Pre-invasive lesions may arise in these fields, however only a minority of pre-invasive neoplasia progresses to overt malignancy. Within this review we discuss recent advances in our understanding of genomic instability processes in normal tissue, describe evolutionary dynamics in pre-invasive disease and highlight current evidence describing how increasing genomic instability may drive the transition from pre-invasive to invasive disease. Appreciation of the evolutionary rulebooks that operate in pre-invasive neoplasia may facilitate screening strategies, risk-stratification of pre-invasive lesions and precipitate novel preventative treatments in at-risk patient populations.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Curr Opin Syst Biol Año: 2017 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Curr Opin Syst Biol Año: 2017 Tipo del documento: Article Pais de publicación: Reino Unido