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Conserved Role for Biofilm Matrix Polysaccharides in Candida auris Drug Resistance.
Dominguez, E G; Zarnowski, R; Choy, H L; Zhao, M; Sanchez, H; Nett, Jeniel E; Andes, D R.
Afiliación
  • Dominguez EG; Department of Medicine, Section of Infectious Disease, University of Wisconsin-Madison, Madison, Wisconsin, USA.
  • Zarnowski R; Department of Medical Microbiology and Immunology, University of Wisconsin-Madison, Madison, Wisconsin, USA.
  • Choy HL; Department of Medicine, Section of Infectious Disease, University of Wisconsin-Madison, Madison, Wisconsin, USA.
  • Zhao M; Department of Medical Microbiology and Immunology, University of Wisconsin-Madison, Madison, Wisconsin, USA.
  • Sanchez H; Department of Medicine, Section of Infectious Disease, University of Wisconsin-Madison, Madison, Wisconsin, USA.
  • Nett JE; Department of Medical Microbiology and Immunology, University of Wisconsin-Madison, Madison, Wisconsin, USA.
  • Andes DR; Department of Medicine, Section of Infectious Disease, University of Wisconsin-Madison, Madison, Wisconsin, USA.
mSphere ; 4(1)2019 01 02.
Article en En | MEDLINE | ID: mdl-30602527
Candida auris has emerged as an outbreak pathogen associated with high mortality. Biofilm formation and linked drug resistance are common among Candida species. Drug sequestration by the biofilm matrix accounts for much of the antifungal tolerance. In this study, we examine the biofilm matrix composition and function for a diverse set of C. auris isolates. We show that matrix sequesters nearly 70% of the available triazole antifungal. Like the biofilms formed by other Candida spp., we find that the matrix of C. auris is rich in mannan-glucan polysaccharides and demonstrate that their hydrolysis reduces drug tolerance. This biofilm matrix resistance mechanism appears conserved among Candida species, including C. aurisIMPORTANCECandida auris is an emerging fungal threat linked to poor patient outcomes. The factors responsible for this apparent increase in pathogenicity remain largely unknown. Biofilm formation has been suggested as an important factor for persistence of this organism in patients and the environment. Our findings reveal one mechanism utilized by C. auris to evade the effect of triazole antifungal therapy during biofilm growth. The conservation of the protective biofilm matrix among Candida spp. suggests that is a promising pan-fungal Candida biofilm drug target.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Candida / Farmacorresistencia Fúngica / Matriz Extracelular de Sustancias Poliméricas / Antifúngicos Límite: Humans Idioma: En Revista: MSphere Año: 2019 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Candida / Farmacorresistencia Fúngica / Matriz Extracelular de Sustancias Poliméricas / Antifúngicos Límite: Humans Idioma: En Revista: MSphere Año: 2019 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos