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Association of RMND1/CCDC170-ESR1 single nucleotide polymorphisms with hip fracture and osteoporosis in postmenopausal women.
Hidalgo-Bravo, A; Parra-Torres, A Y; Casas-Avila, L; Jimenez-Ortega, R F; Ramírez-Salazar, E G; Patiño, N; Rivera-Paredez, B; Salmerón, J; Valdés-Flores, M; Velázquez-Cruz, R.
Afiliación
  • Hidalgo-Bravo A; a Department of Genetics , National Institute of Rehabilitation , Mexico City , Mexico.
  • Parra-Torres AY; b Genomics of Bone Metabolism Laboratory , National Institute of Genomic Medicine (INMEGEN) , Mexico City , Mexico.
  • Casas-Avila L; a Department of Genetics , National Institute of Rehabilitation , Mexico City , Mexico.
  • Jimenez-Ortega RF; b Genomics of Bone Metabolism Laboratory , National Institute of Genomic Medicine (INMEGEN) , Mexico City , Mexico.
  • Ramírez-Salazar EG; b Genomics of Bone Metabolism Laboratory , National Institute of Genomic Medicine (INMEGEN) , Mexico City , Mexico.
  • Patiño N; c National Council for Science and Technology (CONACYT) - Genomics of Bone Metabolism Laboratory , National Institute of Genomic Medicine (INMEGEN) , Mexico City , Mexico.
  • Rivera-Paredez B; d Subdirection of Development of Clinical Applications , National Institute of Genomic Medicine (INMEGEN) , Mexico City , Mexico.
  • Salmerón J; e Academic Unit in Epidemiological Research, Research Center in Policies, Population and Health, School of Medicine , National Autonomous University of Mexico , Mexico City , Mexico.
  • Valdés-Flores M; e Academic Unit in Epidemiological Research, Research Center in Policies, Population and Health, School of Medicine , National Autonomous University of Mexico , Mexico City , Mexico.
  • Velázquez-Cruz R; f Center for Population Health Research , National Institute of Public Health (INSP) , Cuernavaca , Mexico.
Climacteric ; 22(1): 97-104, 2019 02.
Article en En | MEDLINE | ID: mdl-30601066
OBJECTIVE: This study aimed to investigate the association of seven single nucleotide polymorphisms (SNPs) on the RMND1, CCDC170, and ESR1 genes with osteoporosis or hip fracture in a postmenopausal Mexican population. METHODS: We included a group of 400 postmenopausal women from the Health Workers Cohort Study from the Mexican Institute of Social Security. As a replication sample, we recruited 423 postmenopausal women from the National Institute of Rehabilitation. Demographic data were collected through a structured questionnaire. Bone mineral density was assessed using dual X-ray absorptiometry. Individuals were classified as normal, osteopenia, osteoporosis, and fracture, according to World Health Organization criteria. Genotyping was performed using predesigned TaqMan Probes. Linear regression analysis was used to investigate association. RESULTS: All of the analyzed SNPs showed association with at least one of the phenotypes of the study groups. In addition, we observed a region with linkage disequilibrium within the ESR1 gene in all groups. CONCLUSION: This study shows that an association of the SNPs can exist with osteopenia, osteoporosis, or fragility fracture. Our results agree with data published elsewhere, supporting the potential of these loci for the identification of the population at risk. However, additional studies are required to determine the extent of this association for other geographic regions of Mexico.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Densidad Ósea / Osteoporosis Posmenopáusica / Posmenopausia / Polimorfismo de Nucleótido Simple / Fracturas de Cadera Tipo de estudio: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Qualitative_research / Risk_factors_studies Límite: Aged / Female / Humans / Middle aged País/Región como asunto: Mexico Idioma: En Revista: Climacteric Asunto de la revista: GINECOLOGIA Año: 2019 Tipo del documento: Article País de afiliación: México Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Densidad Ósea / Osteoporosis Posmenopáusica / Posmenopausia / Polimorfismo de Nucleótido Simple / Fracturas de Cadera Tipo de estudio: Etiology_studies / Incidence_studies / Observational_studies / Prognostic_studies / Qualitative_research / Risk_factors_studies Límite: Aged / Female / Humans / Middle aged País/Región como asunto: Mexico Idioma: En Revista: Climacteric Asunto de la revista: GINECOLOGIA Año: 2019 Tipo del documento: Article País de afiliación: México Pais de publicación: Reino Unido