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Comparative Analysis of Expression Profiles of Reg Signaling Pathways-Related Genes Between AHF and HCC.
Wang, Gaiping; Cheng, Liya; Chen, Meng; Zhao, Congcong; Gao, Mingxin; Huang, Tiantian; Chu, Peipei; Xu, Cunshuan.
Afiliación
  • Wang G; College of Life Science, Henan Normal University, Xinxiang, 453007, Henan, China. xiaowang0529@163.com.
  • Cheng L; State Key Laboratory Cultivation Base for Cell Differentiation Regulation, Henan Normal University, Xinxiang, Henan, China. xiaowang0529@163.com.
  • Chen M; College of Life Science, Henan Normal University, Xinxiang, 453007, Henan, China.
  • Zhao C; State Key Laboratory Cultivation Base for Cell Differentiation Regulation, Henan Normal University, Xinxiang, Henan, China.
  • Gao M; College of Life Science, Henan Normal University, Xinxiang, 453007, Henan, China.
  • Huang T; State Key Laboratory Cultivation Base for Cell Differentiation Regulation, Henan Normal University, Xinxiang, Henan, China.
  • Chu P; College of Life Science, Henan Normal University, Xinxiang, 453007, Henan, China.
  • Xu C; State Key Laboratory Cultivation Base for Cell Differentiation Regulation, Henan Normal University, Xinxiang, Henan, China.
Biochem Genet ; 57(3): 382-402, 2019 Jun.
Article en En | MEDLINE | ID: mdl-30600408
Regenerating islet-derived protein (Reg) could participate in the occurrence of diabetes mellitus, inflammation, tumors, and other diseased or damaged tissues. However, the correlation of Reg with acute hepatic failure (AHF) and hepatocellular carcinoma (HCC) is poorly defined. To reveal the expression profiles of Reg family and their possible regulatory roles in AHF and HCC, rat models of HCC and AHF were separately established, and Rat Genome 230 2.0 was used to detect expression profiles of Reg-mediated signaling pathways-associated genes from liver tissues in AHF and HCC. The results showed that a total of 79 genes were significantly changed. Among these genes, 67 genes were the AHF-specific genes, 45 genes were the HCC-specific genes, and 33 genes were the common genes. Then, K-means clustering classified these genes into 4 clusters based on the gene expression similarity, and DAVID analysis showed that the above altered genes were mainly associated with stress response, inflammatory response, and cell cycle regulation. Thereafter, IPA software was used to analyze potential effects of these genes, and the predicted results suggested that the Reg-mediated JAK/STAT, NF-κB, MAPK (ERK1/2, P38 and JNK), PLC, and PI3K/AKT signaling pathways may account for the activated inflammation and cell proliferation, and the attenuated apoptosis and cell death during the occurrence of AHF and HCC.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Transducción de Señal / Fallo Hepático Agudo / Carcinoma Hepatocelular / Perfilación de la Expresión Génica / Litostatina / Neoplasias Hepáticas Tipo de estudio: Prognostic_studies Límite: Animals / Humans / Male Idioma: En Revista: Biochem Genet Año: 2019 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Transducción de Señal / Fallo Hepático Agudo / Carcinoma Hepatocelular / Perfilación de la Expresión Génica / Litostatina / Neoplasias Hepáticas Tipo de estudio: Prognostic_studies Límite: Animals / Humans / Male Idioma: En Revista: Biochem Genet Año: 2019 Tipo del documento: Article País de afiliación: China Pais de publicación: Estados Unidos